Cortical structural abnormalities in deficit versus nondeficit schizophrenia

Bernard A. Fischer, William R. Keller, Celso Arango, Godfrey D. Pearlson, Robert P. McMahon, Walter A. Meyer, Alan Francis, Brian Kirkpatrick, William T. Carpenter, Robert W. Buchanan

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Objective: To examine the structural integrity of the dorsolateral prefrontal-basal ganglia-thalamocortical circuit in people with the deficit form of schizophrenia. Method: A three-dimensional structural MRI sequence was used to conduct morphometric assessments of cortical and subcortical regions in deficit and nondeficit outpatients with schizophrenia and healthy controls. Results: The superior prefrontal and superior and middle temporal gyral gray matter volumes were significantly smaller in the deficit versus the nondeficit group and normal control groups. There were no significant group differences in examined subcortical structures. Conclusion: People with deficit schizophrenia are characterized by selective reductions in the prefrontal and temporal cortex.

Original languageEnglish (US)
Pages (from-to)51-54
Number of pages4
JournalSchizophrenia Research
Issue number1-3
StatePublished - Apr 2012
Externally publishedYes


  • Deficit syndrome
  • Frontal lobe
  • Schizophrenia
  • Structural MRI
  • Temporal lobe

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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