Cortical structural abnormalities in deficit versus nondeficit schizophrenia

Bernard A. Fischer; William R. Keller; Celso Arango; Godfrey D. Pearlson; Robert P. McMahon; Walter A. Meyer; Alan Francis; Brian Kirkpatrick; William T. Carpenter; Robert W. Buchanan

doi:10.1016/j.schres.2012.01.030

Cortical structural abnormalities in deficit versus nondeficit schizophrenia

Bernard A. Fischer, William R. Keller, Celso Arango, Godfrey D. Pearlson, Robert P. McMahon, Walter A. Meyer, Alan Francis, Brian Kirkpatrick, William T. Carpenter, Robert W. Buchanan

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Objective: To examine the structural integrity of the dorsolateral prefrontal-basal ganglia-thalamocortical circuit in people with the deficit form of schizophrenia. Method: A three-dimensional structural MRI sequence was used to conduct morphometric assessments of cortical and subcortical regions in deficit and nondeficit outpatients with schizophrenia and healthy controls. Results: The superior prefrontal and superior and middle temporal gyral gray matter volumes were significantly smaller in the deficit versus the nondeficit group and normal control groups. There were no significant group differences in examined subcortical structures. Conclusion: People with deficit schizophrenia are characterized by selective reductions in the prefrontal and temporal cortex.

Original language	English (US)
Pages (from-to)	51-54
Number of pages	4
Journal	Schizophrenia Research
Volume	136
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2012.01.030
State	Published - Apr 2012
Externally published	Yes

Keywords

Deficit syndrome
Frontal lobe
Schizophrenia
Structural MRI
Temporal lobe

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.schres.2012.01.030

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title = "Cortical structural abnormalities in deficit versus nondeficit schizophrenia",

abstract = "Objective: To examine the structural integrity of the dorsolateral prefrontal-basal ganglia-thalamocortical circuit in people with the deficit form of schizophrenia. Method: A three-dimensional structural MRI sequence was used to conduct morphometric assessments of cortical and subcortical regions in deficit and nondeficit outpatients with schizophrenia and healthy controls. Results: The superior prefrontal and superior and middle temporal gyral gray matter volumes were significantly smaller in the deficit versus the nondeficit group and normal control groups. There were no significant group differences in examined subcortical structures. Conclusion: People with deficit schizophrenia are characterized by selective reductions in the prefrontal and temporal cortex.",

keywords = "Deficit syndrome, Frontal lobe, Schizophrenia, Structural MRI, Temporal lobe",

author = "Fischer, {Bernard A.} and Keller, {William R.} and Celso Arango and Pearlson, {Godfrey D.} and McMahon, {Robert P.} and Meyer, {Walter A.} and Alan Francis and Brian Kirkpatrick and Carpenter, {William T.} and Buchanan, {Robert W.}",

note = "Funding Information: Funding for this study was provided by an NIMH FIRST Award, MH48225, to Dr. Buchanan. The NIMH had no further role in the study design; the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. ",

year = "2012",

month = apr,

doi = "10.1016/j.schres.2012.01.030",

language = "English (US)",

volume = "136",

pages = "51--54",

journal = "Schizophrenia Research",

issn = "0920-9964",

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AU - Fischer, Bernard A.

AU - Keller, William R.

AU - Arango, Celso

AU - Pearlson, Godfrey D.

AU - McMahon, Robert P.

AU - Meyer, Walter A.

AU - Francis, Alan

AU - Kirkpatrick, Brian

AU - Carpenter, William T.

AU - Buchanan, Robert W.

N1 - Funding Information: Funding for this study was provided by an NIMH FIRST Award, MH48225, to Dr. Buchanan. The NIMH had no further role in the study design; the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.

PY - 2012/4

Y1 - 2012/4

N2 - Objective: To examine the structural integrity of the dorsolateral prefrontal-basal ganglia-thalamocortical circuit in people with the deficit form of schizophrenia. Method: A three-dimensional structural MRI sequence was used to conduct morphometric assessments of cortical and subcortical regions in deficit and nondeficit outpatients with schizophrenia and healthy controls. Results: The superior prefrontal and superior and middle temporal gyral gray matter volumes were significantly smaller in the deficit versus the nondeficit group and normal control groups. There were no significant group differences in examined subcortical structures. Conclusion: People with deficit schizophrenia are characterized by selective reductions in the prefrontal and temporal cortex.

AB - Objective: To examine the structural integrity of the dorsolateral prefrontal-basal ganglia-thalamocortical circuit in people with the deficit form of schizophrenia. Method: A three-dimensional structural MRI sequence was used to conduct morphometric assessments of cortical and subcortical regions in deficit and nondeficit outpatients with schizophrenia and healthy controls. Results: The superior prefrontal and superior and middle temporal gyral gray matter volumes were significantly smaller in the deficit versus the nondeficit group and normal control groups. There were no significant group differences in examined subcortical structures. Conclusion: People with deficit schizophrenia are characterized by selective reductions in the prefrontal and temporal cortex.

KW - Deficit syndrome

KW - Frontal lobe

KW - Schizophrenia

KW - Structural MRI

KW - Temporal lobe

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ER -

Cortical structural abnormalities in deficit versus nondeficit schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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