Cortical sites of sustained and divided attention in normal elderly humans

Peter Johannsen, Johannes Jakobsen, Peter Bruhn, Søren B. Hansen, Antony Gee, Hans Stødkilde-Jørgensen, Albert Gjedde

Research output: Contribution to journalArticle

Abstract

Human brain mechanisms subserving attention have been assigned to prefrontal, midfrontal, and posterior parietal cortices, as well as to the anterior cingulate and the thalamus. To map these mechanisms in the brain, most studies have used selective attention tasks; few studies have mapped the brain under sustained or divided attention. The present study was designed to create maps of regional activity associated with sustained and divided attention using two different sensory modalities: visual checkerboard stimulation and vibrotactile stimulation of the right hand. Five cerebral PE- tomograms of 15O-labeled water uptake were acquired from 16 elderly healthy subjects during sustained or divided attention to the frequency of stimulation. To locate active brain regions, the t-statistic map of relative changes in cerebral blood flow was coregistered to the subjects' averaged brain MR images and to the standard Talairach brain coordinate system. Attention was associated with activity in two sites, the right middle frontal gyrus (Brodmann area 46) and the right inferior parietal lobule (Brodmann area 40). The frontal site was more active when the subjects attended to the visual stimulus and when the attention was divided, while the parietal site was more active during attention to the vibrotactile stimulus and during simple sustained attention. Our observations are consistent with the hypotheses (1) that the right posterior parietal attention center subserves attention to several sensory modalities and (2) that a cortical network of specific neuronal sites subserves both sustained and divided attention. These hypotheses must be tested in further studies.

Original languageEnglish (US)
Pages (from-to)145-155
Number of pages11
JournalNeuroImage
Volume6
Issue number3
DOIs
StatePublished - Oct 1997
Externally publishedYes

Fingerprint

Brain
Parietal Lobe
Cerebrovascular Circulation
Photic Stimulation
Gyrus Cinguli
Thalamus
Healthy Volunteers
Hand
Water

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Johannsen, P., Jakobsen, J., Bruhn, P., Hansen, S. B., Gee, A., Stødkilde-Jørgensen, H., & Gjedde, A. (1997). Cortical sites of sustained and divided attention in normal elderly humans. NeuroImage, 6(3), 145-155. https://doi.org/10.1006/nimg.1997.0292

Cortical sites of sustained and divided attention in normal elderly humans. / Johannsen, Peter; Jakobsen, Johannes; Bruhn, Peter; Hansen, Søren B.; Gee, Antony; Stødkilde-Jørgensen, Hans; Gjedde, Albert.

In: NeuroImage, Vol. 6, No. 3, 10.1997, p. 145-155.

Research output: Contribution to journalArticle

Johannsen, P, Jakobsen, J, Bruhn, P, Hansen, SB, Gee, A, Stødkilde-Jørgensen, H & Gjedde, A 1997, 'Cortical sites of sustained and divided attention in normal elderly humans', NeuroImage, vol. 6, no. 3, pp. 145-155. https://doi.org/10.1006/nimg.1997.0292
Johannsen P, Jakobsen J, Bruhn P, Hansen SB, Gee A, Stødkilde-Jørgensen H et al. Cortical sites of sustained and divided attention in normal elderly humans. NeuroImage. 1997 Oct;6(3):145-155. https://doi.org/10.1006/nimg.1997.0292
Johannsen, Peter ; Jakobsen, Johannes ; Bruhn, Peter ; Hansen, Søren B. ; Gee, Antony ; Stødkilde-Jørgensen, Hans ; Gjedde, Albert. / Cortical sites of sustained and divided attention in normal elderly humans. In: NeuroImage. 1997 ; Vol. 6, No. 3. pp. 145-155.
@article{f956bbfaf713492d9c2f67ca5bf2be90,
title = "Cortical sites of sustained and divided attention in normal elderly humans",
abstract = "Human brain mechanisms subserving attention have been assigned to prefrontal, midfrontal, and posterior parietal cortices, as well as to the anterior cingulate and the thalamus. To map these mechanisms in the brain, most studies have used selective attention tasks; few studies have mapped the brain under sustained or divided attention. The present study was designed to create maps of regional activity associated with sustained and divided attention using two different sensory modalities: visual checkerboard stimulation and vibrotactile stimulation of the right hand. Five cerebral PE- tomograms of 15O-labeled water uptake were acquired from 16 elderly healthy subjects during sustained or divided attention to the frequency of stimulation. To locate active brain regions, the t-statistic map of relative changes in cerebral blood flow was coregistered to the subjects' averaged brain MR images and to the standard Talairach brain coordinate system. Attention was associated with activity in two sites, the right middle frontal gyrus (Brodmann area 46) and the right inferior parietal lobule (Brodmann area 40). The frontal site was more active when the subjects attended to the visual stimulus and when the attention was divided, while the parietal site was more active during attention to the vibrotactile stimulus and during simple sustained attention. Our observations are consistent with the hypotheses (1) that the right posterior parietal attention center subserves attention to several sensory modalities and (2) that a cortical network of specific neuronal sites subserves both sustained and divided attention. These hypotheses must be tested in further studies.",
author = "Peter Johannsen and Johannes Jakobsen and Peter Bruhn and Hansen, {S{\o}ren B.} and Antony Gee and Hans St{\o}dkilde-J{\o}rgensen and Albert Gjedde",
year = "1997",
month = "10",
doi = "10.1006/nimg.1997.0292",
language = "English (US)",
volume = "6",
pages = "145--155",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Cortical sites of sustained and divided attention in normal elderly humans

AU - Johannsen, Peter

AU - Jakobsen, Johannes

AU - Bruhn, Peter

AU - Hansen, Søren B.

AU - Gee, Antony

AU - Stødkilde-Jørgensen, Hans

AU - Gjedde, Albert

PY - 1997/10

Y1 - 1997/10

N2 - Human brain mechanisms subserving attention have been assigned to prefrontal, midfrontal, and posterior parietal cortices, as well as to the anterior cingulate and the thalamus. To map these mechanisms in the brain, most studies have used selective attention tasks; few studies have mapped the brain under sustained or divided attention. The present study was designed to create maps of regional activity associated with sustained and divided attention using two different sensory modalities: visual checkerboard stimulation and vibrotactile stimulation of the right hand. Five cerebral PE- tomograms of 15O-labeled water uptake were acquired from 16 elderly healthy subjects during sustained or divided attention to the frequency of stimulation. To locate active brain regions, the t-statistic map of relative changes in cerebral blood flow was coregistered to the subjects' averaged brain MR images and to the standard Talairach brain coordinate system. Attention was associated with activity in two sites, the right middle frontal gyrus (Brodmann area 46) and the right inferior parietal lobule (Brodmann area 40). The frontal site was more active when the subjects attended to the visual stimulus and when the attention was divided, while the parietal site was more active during attention to the vibrotactile stimulus and during simple sustained attention. Our observations are consistent with the hypotheses (1) that the right posterior parietal attention center subserves attention to several sensory modalities and (2) that a cortical network of specific neuronal sites subserves both sustained and divided attention. These hypotheses must be tested in further studies.

AB - Human brain mechanisms subserving attention have been assigned to prefrontal, midfrontal, and posterior parietal cortices, as well as to the anterior cingulate and the thalamus. To map these mechanisms in the brain, most studies have used selective attention tasks; few studies have mapped the brain under sustained or divided attention. The present study was designed to create maps of regional activity associated with sustained and divided attention using two different sensory modalities: visual checkerboard stimulation and vibrotactile stimulation of the right hand. Five cerebral PE- tomograms of 15O-labeled water uptake were acquired from 16 elderly healthy subjects during sustained or divided attention to the frequency of stimulation. To locate active brain regions, the t-statistic map of relative changes in cerebral blood flow was coregistered to the subjects' averaged brain MR images and to the standard Talairach brain coordinate system. Attention was associated with activity in two sites, the right middle frontal gyrus (Brodmann area 46) and the right inferior parietal lobule (Brodmann area 40). The frontal site was more active when the subjects attended to the visual stimulus and when the attention was divided, while the parietal site was more active during attention to the vibrotactile stimulus and during simple sustained attention. Our observations are consistent with the hypotheses (1) that the right posterior parietal attention center subserves attention to several sensory modalities and (2) that a cortical network of specific neuronal sites subserves both sustained and divided attention. These hypotheses must be tested in further studies.

UR - http://www.scopus.com/inward/record.url?scp=0030668367&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030668367&partnerID=8YFLogxK

U2 - 10.1006/nimg.1997.0292

DO - 10.1006/nimg.1997.0292

M3 - Article

C2 - 9344819

AN - SCOPUS:0030668367

VL - 6

SP - 145

EP - 155

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 3

ER -