Cortical responses to sustained and divided attention in Alzheimer's disease

Peter Johannsen, Johannes Jakobsen, Peter Bruhn, Albert Gjedde

Research output: Contribution to journalArticle

Abstract

Neuropsychological data suggests that divided attention is more impaired than sustained attention during the early phases of Alzheimer's disease. The purpose of the present study was to compare cerebral activation patterns during sustained and divided attention between Alzheimer patients and healthy elderly. The O-15-water PET activation method was used to map sustained and divided attention in 16 patients with Alzheimer's disease (mean age ± SD: 68 ± 5 years; MMSE: 11-25, mean ± SD = 19.5 ± 4.9) and in 16 healthy age- matched control subjects. After stereotactical normalization, voxel-by-voxel t statistics was used to assess the significance of activated brain areas and to compare activations between patients and control subjects. In the healthy elderly, sustained and divided attention both elicited activation of the right inferior parietal lobule, and the right middle frontal gyrus, whereas the anterior cingulate gyrus was activated during sustained attention only. Only medial frontal structures (Brodmann Area (BA) 32/34) were activated in Alzheimer patients, and both frontal (BA-10), posterior cingulate (BA-23/31), and subcortical sites were deactivated. Compared to the healthy elderly, the activations in the patients of the right medial (BA-11) superior (BA-10) and inferior (BA-47) frontal gyri, the right middle temporal (BA-20), and the left lingual (BA-17) gyri were significantly reduced. More cortical sites differed statistically between Alzheimer patients and control subjects during divided than during sustained attention. The activation pattern elicited by attention supports the neuropsychological data that divided attention is more impaired than sustained attention in early Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)269-281
Number of pages13
JournalNeuroImage
Volume10
Issue number3 I
DOIs
StatePublished - Sep 1999
Externally publishedYes

Fingerprint

Alzheimer Disease
Gyrus Cinguli
Parietal Lobe
Patient Rights
Tongue
Water
Brain

Keywords

  • Alzheimer's disease
  • Attention
  • Parietal cortex
  • PET activation
  • Prefrontal cortex

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Johannsen, P., Jakobsen, J., Bruhn, P., & Gjedde, A. (1999). Cortical responses to sustained and divided attention in Alzheimer's disease. NeuroImage, 10(3 I), 269-281. https://doi.org/10.1006/nimg.1999.0475

Cortical responses to sustained and divided attention in Alzheimer's disease. / Johannsen, Peter; Jakobsen, Johannes; Bruhn, Peter; Gjedde, Albert.

In: NeuroImage, Vol. 10, No. 3 I, 09.1999, p. 269-281.

Research output: Contribution to journalArticle

Johannsen, P, Jakobsen, J, Bruhn, P & Gjedde, A 1999, 'Cortical responses to sustained and divided attention in Alzheimer's disease', NeuroImage, vol. 10, no. 3 I, pp. 269-281. https://doi.org/10.1006/nimg.1999.0475
Johannsen, Peter ; Jakobsen, Johannes ; Bruhn, Peter ; Gjedde, Albert. / Cortical responses to sustained and divided attention in Alzheimer's disease. In: NeuroImage. 1999 ; Vol. 10, No. 3 I. pp. 269-281.
@article{14da420fdf124429b8e7cf29fe3115f6,
title = "Cortical responses to sustained and divided attention in Alzheimer's disease",
abstract = "Neuropsychological data suggests that divided attention is more impaired than sustained attention during the early phases of Alzheimer's disease. The purpose of the present study was to compare cerebral activation patterns during sustained and divided attention between Alzheimer patients and healthy elderly. The O-15-water PET activation method was used to map sustained and divided attention in 16 patients with Alzheimer's disease (mean age ± SD: 68 ± 5 years; MMSE: 11-25, mean ± SD = 19.5 ± 4.9) and in 16 healthy age- matched control subjects. After stereotactical normalization, voxel-by-voxel t statistics was used to assess the significance of activated brain areas and to compare activations between patients and control subjects. In the healthy elderly, sustained and divided attention both elicited activation of the right inferior parietal lobule, and the right middle frontal gyrus, whereas the anterior cingulate gyrus was activated during sustained attention only. Only medial frontal structures (Brodmann Area (BA) 32/34) were activated in Alzheimer patients, and both frontal (BA-10), posterior cingulate (BA-23/31), and subcortical sites were deactivated. Compared to the healthy elderly, the activations in the patients of the right medial (BA-11) superior (BA-10) and inferior (BA-47) frontal gyri, the right middle temporal (BA-20), and the left lingual (BA-17) gyri were significantly reduced. More cortical sites differed statistically between Alzheimer patients and control subjects during divided than during sustained attention. The activation pattern elicited by attention supports the neuropsychological data that divided attention is more impaired than sustained attention in early Alzheimer's disease.",
keywords = "Alzheimer's disease, Attention, Parietal cortex, PET activation, Prefrontal cortex",
author = "Peter Johannsen and Johannes Jakobsen and Peter Bruhn and Albert Gjedde",
year = "1999",
month = "9",
doi = "10.1006/nimg.1999.0475",
language = "English (US)",
volume = "10",
pages = "269--281",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",
number = "3 I",

}

TY - JOUR

T1 - Cortical responses to sustained and divided attention in Alzheimer's disease

AU - Johannsen, Peter

AU - Jakobsen, Johannes

AU - Bruhn, Peter

AU - Gjedde, Albert

PY - 1999/9

Y1 - 1999/9

N2 - Neuropsychological data suggests that divided attention is more impaired than sustained attention during the early phases of Alzheimer's disease. The purpose of the present study was to compare cerebral activation patterns during sustained and divided attention between Alzheimer patients and healthy elderly. The O-15-water PET activation method was used to map sustained and divided attention in 16 patients with Alzheimer's disease (mean age ± SD: 68 ± 5 years; MMSE: 11-25, mean ± SD = 19.5 ± 4.9) and in 16 healthy age- matched control subjects. After stereotactical normalization, voxel-by-voxel t statistics was used to assess the significance of activated brain areas and to compare activations between patients and control subjects. In the healthy elderly, sustained and divided attention both elicited activation of the right inferior parietal lobule, and the right middle frontal gyrus, whereas the anterior cingulate gyrus was activated during sustained attention only. Only medial frontal structures (Brodmann Area (BA) 32/34) were activated in Alzheimer patients, and both frontal (BA-10), posterior cingulate (BA-23/31), and subcortical sites were deactivated. Compared to the healthy elderly, the activations in the patients of the right medial (BA-11) superior (BA-10) and inferior (BA-47) frontal gyri, the right middle temporal (BA-20), and the left lingual (BA-17) gyri were significantly reduced. More cortical sites differed statistically between Alzheimer patients and control subjects during divided than during sustained attention. The activation pattern elicited by attention supports the neuropsychological data that divided attention is more impaired than sustained attention in early Alzheimer's disease.

AB - Neuropsychological data suggests that divided attention is more impaired than sustained attention during the early phases of Alzheimer's disease. The purpose of the present study was to compare cerebral activation patterns during sustained and divided attention between Alzheimer patients and healthy elderly. The O-15-water PET activation method was used to map sustained and divided attention in 16 patients with Alzheimer's disease (mean age ± SD: 68 ± 5 years; MMSE: 11-25, mean ± SD = 19.5 ± 4.9) and in 16 healthy age- matched control subjects. After stereotactical normalization, voxel-by-voxel t statistics was used to assess the significance of activated brain areas and to compare activations between patients and control subjects. In the healthy elderly, sustained and divided attention both elicited activation of the right inferior parietal lobule, and the right middle frontal gyrus, whereas the anterior cingulate gyrus was activated during sustained attention only. Only medial frontal structures (Brodmann Area (BA) 32/34) were activated in Alzheimer patients, and both frontal (BA-10), posterior cingulate (BA-23/31), and subcortical sites were deactivated. Compared to the healthy elderly, the activations in the patients of the right medial (BA-11) superior (BA-10) and inferior (BA-47) frontal gyri, the right middle temporal (BA-20), and the left lingual (BA-17) gyri were significantly reduced. More cortical sites differed statistically between Alzheimer patients and control subjects during divided than during sustained attention. The activation pattern elicited by attention supports the neuropsychological data that divided attention is more impaired than sustained attention in early Alzheimer's disease.

KW - Alzheimer's disease

KW - Attention

KW - Parietal cortex

KW - PET activation

KW - Prefrontal cortex

UR - http://www.scopus.com/inward/record.url?scp=0032853868&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032853868&partnerID=8YFLogxK

U2 - 10.1006/nimg.1999.0475

DO - 10.1006/nimg.1999.0475

M3 - Article

C2 - 10458942

AN - SCOPUS:0032853868

VL - 10

SP - 269

EP - 281

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 3 I

ER -