Cortical networks subserving the perception of tinnitus - A PET study

Frank Mirz, Albert Gjedde, Koichi Ishizu, Christian Brahe Pedersen

Research output: Contribution to journalArticle

Abstract

Subjective tinnitus is an auditory phantom perception that may arise from any aberrant signal within the auditory system. Further processing of this signal and the conscious perception of tinnitus takes place in the cerebral cortex. A few functional brain-imaging studies have been performed to elucidate the underlying cerebral mechanisms of this perception. These studies mostly concern rare types of tinnitus (e.g. tinnitus changeable by oral-facial movements), or compared tinnitus patients with healthy volunteers. These studies attributed variable activation of the primary auditory cortices, associative auditory cortices and the left hippocampus to the perception of tinnitus. Based on these heterogeneous results, no consensus on the underlying mechanisms has been reached. The aim of the present study was to obtain further details of the central perception and processing of the tinnitus signal. Positron emission tomography (PET) was used to map the tinnitus-specific central activity. By contrasting PET-images of suppressed tinnitus with PET-images of the habitual tinnitus sensation, we were able to identify a right prefrontal-temporal network associated with the perception of tinnitus. Besides the evidence of activation of associative auditory sensory regions, the results indicated that activation of cortical centres subserving attention and emotion may underlie the continuous irritability associated with severe tinnitus.

Original languageEnglish (US)
Pages (from-to)241-243
Number of pages3
JournalActa oto-laryngologica. Supplementum
Issue number543
StatePublished - 2000
Externally publishedYes

Fingerprint

Tinnitus
Positron-Emission Tomography
Auditory Cortex
Auditory Perception
Functional Neuroimaging
Cerebral Cortex
Hippocampus
Consensus
Healthy Volunteers
Emotions

Keywords

  • Attention
  • Emotion
  • Functional neuroimaging
  • Positron emission tomography
  • Tinnitus

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Mirz, F., Gjedde, A., Ishizu, K., & Pedersen, C. B. (2000). Cortical networks subserving the perception of tinnitus - A PET study. Acta oto-laryngologica. Supplementum, (543), 241-243.

Cortical networks subserving the perception of tinnitus - A PET study. / Mirz, Frank; Gjedde, Albert; Ishizu, Koichi; Pedersen, Christian Brahe.

In: Acta oto-laryngologica. Supplementum, No. 543, 2000, p. 241-243.

Research output: Contribution to journalArticle

Mirz, F, Gjedde, A, Ishizu, K & Pedersen, CB 2000, 'Cortical networks subserving the perception of tinnitus - A PET study', Acta oto-laryngologica. Supplementum, no. 543, pp. 241-243.
Mirz, Frank ; Gjedde, Albert ; Ishizu, Koichi ; Pedersen, Christian Brahe. / Cortical networks subserving the perception of tinnitus - A PET study. In: Acta oto-laryngologica. Supplementum. 2000 ; No. 543. pp. 241-243.
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