Cortical high-gamma responses in auditory processing

Purpose: This tutorial provides an introduction to cortical auditory spectral responses, focusing on event-related activity in the high-gamma frequencies (60-150 Hz), their recent emergence in neuroscience research, and potential clinical applications. Method: Auditory high-gamma responses are described and compared with traditional cortical evoked responses, including the auditory evoked N1 response. Methods for acquiring and analyzing spectral responses, including timefrequency analyses, are discussed and contrasted with more familiar time-domain averaging approaches. Four cases are presented illustrating high-gamma response patterns associated with normal and impaired auditory processing. Conclusions: Cortical auditory high-gamma responses may provide a useful clinical measure of auditory processing.