Cortical circumferential profile of SPECT cerebral perfusion in Alzheimer's disease

Gordon J. Harris, Jonathan M Links, Godfrey D. Pearlson, Edwaldo E. Camargo

Research output: Contribution to journalArticle

Abstract

We developed a semiautomatic method termed "cortical circumferential profiling" for objective analysis of cerebral cortex function in emission tomographic neuroimaging studies. This method treats cortex as a continuous ring near the outer brain edge. A computer algorithm samples the cortex at 60 contiguous, equiangular locations, using 1-cm2 samples. These values are plotted as a function of cortical angle to produce the cortical circumferential profile. This method was used in a study of regional cerebral perfusion in 15 patients with Alzheimer's disease and 8 elderly control subjects using N-isopropyl [I-123]-iodoamphetamine. Cortical circumferential profiling decreases variability, examines the entire cortex within slices at preselected levels above the orbital-meatal line, and facilitates intrasubject and intersubject comparisons.

Original languageEnglish (US)
Pages (from-to)167-180
Number of pages14
JournalPsychiatry Research
Volume40
Issue number3
StatePublished - Nov 1991

Fingerprint

Single-Photon Emission-Computed Tomography
Alzheimer Disease
Perfusion
Neuroimaging
Cerebral Cortex
Brain

Keywords

  • Alzheimer's disease
  • Cerebral emission computed tomography
  • cortical circumferential profile
  • regional cerebral blood flow
  • semiautomated quantification

ASJC Scopus subject areas

  • Psychology(all)
  • Biological Psychiatry
  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging

Cite this

Cortical circumferential profile of SPECT cerebral perfusion in Alzheimer's disease. / Harris, Gordon J.; Links, Jonathan M; Pearlson, Godfrey D.; Camargo, Edwaldo E.

In: Psychiatry Research, Vol. 40, No. 3, 11.1991, p. 167-180.

Research output: Contribution to journalArticle

Harris, GJ, Links, JM, Pearlson, GD & Camargo, EE 1991, 'Cortical circumferential profile of SPECT cerebral perfusion in Alzheimer's disease', Psychiatry Research, vol. 40, no. 3, pp. 167-180.
Harris, Gordon J. ; Links, Jonathan M ; Pearlson, Godfrey D. ; Camargo, Edwaldo E. / Cortical circumferential profile of SPECT cerebral perfusion in Alzheimer's disease. In: Psychiatry Research. 1991 ; Vol. 40, No. 3. pp. 167-180.
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