TY - JOUR
T1 - Cortical and Subcortical Circuits for Cross-Modal Plasticity Induced by Loss of Vision
AU - Ewall, Gabrielle
AU - Parkins, Samuel
AU - Lin, Amy
AU - Jaoui, Yanis
AU - Lee, Hey Kyoung
N1 - Funding Information:
This work was supported by National Institutes of Health (NIH) grant R01-EY014882 to H-KL and NRSA F31-EY031946 to SP.
Publisher Copyright:
© Copyright © 2021 Ewall, Parkins, Lin, Jaoui and Lee.
PY - 2021/5/25
Y1 - 2021/5/25
N2 - Cortical areas are highly interconnected both via cortical and subcortical pathways, and primary sensory cortices are not isolated from this general structure. In primary sensory cortical areas, these pre-existing functional connections serve to provide contextual information for sensory processing and can mediate adaptation when a sensory modality is lost. Cross-modal plasticity in broad terms refers to widespread plasticity across the brain in response to losing a sensory modality, and largely involves two distinct changes: cross-modal recruitment and compensatory plasticity. The former involves recruitment of the deprived sensory area, which includes the deprived primary sensory cortex, for processing the remaining senses. Compensatory plasticity refers to plasticity in the remaining sensory areas, including the spared primary sensory cortices, to enhance the processing of its own sensory inputs. Here, we will summarize potential cellular plasticity mechanisms involved in cross-modal recruitment and compensatory plasticity, and review cortical and subcortical circuits to the primary sensory cortices which can mediate cross-modal plasticity upon loss of vision.
AB - Cortical areas are highly interconnected both via cortical and subcortical pathways, and primary sensory cortices are not isolated from this general structure. In primary sensory cortical areas, these pre-existing functional connections serve to provide contextual information for sensory processing and can mediate adaptation when a sensory modality is lost. Cross-modal plasticity in broad terms refers to widespread plasticity across the brain in response to losing a sensory modality, and largely involves two distinct changes: cross-modal recruitment and compensatory plasticity. The former involves recruitment of the deprived sensory area, which includes the deprived primary sensory cortex, for processing the remaining senses. Compensatory plasticity refers to plasticity in the remaining sensory areas, including the spared primary sensory cortices, to enhance the processing of its own sensory inputs. Here, we will summarize potential cellular plasticity mechanisms involved in cross-modal recruitment and compensatory plasticity, and review cortical and subcortical circuits to the primary sensory cortices which can mediate cross-modal plasticity upon loss of vision.
KW - cortical circuits
KW - cortical plasticity
KW - cross-modal plasticity
KW - functional connectivity
KW - metaplasticity
KW - multi-sensory interaction
KW - sensory loss
KW - subcortical circuits
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U2 - 10.3389/fncir.2021.665009
DO - 10.3389/fncir.2021.665009
M3 - Article
C2 - 34113240
AN - SCOPUS:85107374088
SN - 1662-5110
VL - 15
JO - Frontiers in neural circuits
JF - Frontiers in neural circuits
M1 - 665009
ER -