Cortical abnormality in schizophrenia: An in vitro application of the gyrification index

Jennifer J. Kulynych, Laura F. Luevano, Douglas W. Jones, Daniel Weinberger

Research output: Contribution to journalArticle

Abstract

To investigate the hypothesis that patients with schizophrenia exhibit gross cortical abnormalities of developmental origin, we utilized the gyrification index (GI) (ratio of inner to outer cortical contours), a measure of overall cortical folding, in an in vivo magnetic resonance imaging study of young, strongly right-handed male patients and controls. The two groups did not differ with respect to whole-brain volume, age, or handedness. In an examination confined to the left hemisphere, mean GI values were significantly reduced in the patient group in both anterior and posterior regions. Neither age nor length of illness were found to be significant predictors of GI variance in the patient group, suggesting that GI reductions do not result from an ongoing atrophic process. Rather, these results are consistent with the hypothesis of neurodevelopmental abnormalities in schizophrenia that result in an overall reduction in cortical folding.

Original languageEnglish (US)
Pages (from-to)995-999
Number of pages5
JournalBiological Psychiatry
Volume41
Issue number10
DOIs
StatePublished - May 15 1997
Externally publishedYes

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Schizophrenia
Functional Laterality
Magnetic Resonance Imaging
In Vitro Techniques
Brain

Keywords

  • cortex
  • gyrification
  • magnetic resonance imaging
  • schizophrenia

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Cortical abnormality in schizophrenia : An in vitro application of the gyrification index. / Kulynych, Jennifer J.; Luevano, Laura F.; Jones, Douglas W.; Weinberger, Daniel.

In: Biological Psychiatry, Vol. 41, No. 10, 15.05.1997, p. 995-999.

Research output: Contribution to journalArticle

Kulynych, Jennifer J. ; Luevano, Laura F. ; Jones, Douglas W. ; Weinberger, Daniel. / Cortical abnormality in schizophrenia : An in vitro application of the gyrification index. In: Biological Psychiatry. 1997 ; Vol. 41, No. 10. pp. 995-999.
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