Cortex commands the performance of skilled movement

Jian Zhong Guo, Austin Graves, Wendy W. Guo, Jihong Zheng, Allen Lee, Juan Rodríguez-Gonzá Lez, Nuo Li, John J. Macklin, James W. Phillips, Brett D. Mensh, Kristin Branson, Adam W. Hantman

Research output: Contribution to journalArticle

Abstract

Mammalian cerebral cortex is accepted as being critical for voluntary motor control, but what functions depend on cortex is still unclear. Here we used rapid, reversible optogenetic inhibition to test the role of cortex during a head-fixed task in which mice reach, grab, and eat a food pellet. Sudden cortical inhibition blocked initiation or froze execution of this skilled prehension behavior, but left untrained forelimb movements unaffected. Unexpectedly, kinematically normal prehension occurred immediately after cortical inhibition, even during rest periods lacking cue and pellet. This ‘rebound’ prehension was only evoked in trained and food- deprived animals, suggesting that a motivation-gated motor engram sufficient to evoke prehension is activated at inhibition’s end. These results demonstrate the necessity and sufficiency of cortical activity for enacting a learned skill.

Original languageEnglish (US)
Article numbere10774
JournaleLife
Volume4
Issue numberDECEMBER2015
DOIs
StatePublished - Dec 2 2015
Externally publishedYes

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Animals
Optogenetics
Food
Forelimb
Cerebral Cortex
Cues
Motivation
Head
Inhibition (Psychology)

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Guo, J. Z., Graves, A., Guo, W. W., Zheng, J., Lee, A., Rodríguez-Gonzá Lez, J., ... Hantman, A. W. (2015). Cortex commands the performance of skilled movement. eLife, 4(DECEMBER2015), [e10774]. https://doi.org/10.7554/eLife.10774

Cortex commands the performance of skilled movement. / Guo, Jian Zhong; Graves, Austin; Guo, Wendy W.; Zheng, Jihong; Lee, Allen; Rodríguez-Gonzá Lez, Juan; Li, Nuo; Macklin, John J.; Phillips, James W.; Mensh, Brett D.; Branson, Kristin; Hantman, Adam W.

In: eLife, Vol. 4, No. DECEMBER2015, e10774, 02.12.2015.

Research output: Contribution to journalArticle

Guo, JZ, Graves, A, Guo, WW, Zheng, J, Lee, A, Rodríguez-Gonzá Lez, J, Li, N, Macklin, JJ, Phillips, JW, Mensh, BD, Branson, K & Hantman, AW 2015, 'Cortex commands the performance of skilled movement', eLife, vol. 4, no. DECEMBER2015, e10774. https://doi.org/10.7554/eLife.10774
Guo JZ, Graves A, Guo WW, Zheng J, Lee A, Rodríguez-Gonzá Lez J et al. Cortex commands the performance of skilled movement. eLife. 2015 Dec 2;4(DECEMBER2015). e10774. https://doi.org/10.7554/eLife.10774
Guo, Jian Zhong ; Graves, Austin ; Guo, Wendy W. ; Zheng, Jihong ; Lee, Allen ; Rodríguez-Gonzá Lez, Juan ; Li, Nuo ; Macklin, John J. ; Phillips, James W. ; Mensh, Brett D. ; Branson, Kristin ; Hantman, Adam W. / Cortex commands the performance of skilled movement. In: eLife. 2015 ; Vol. 4, No. DECEMBER2015.
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