Correlations between serum levels of beta amyloid, cerebrospinal levels of tau and phospho tau, and delayed response tasks in young and aged cynomolgus monkeys (Macaca fascicularis)

H. S. Darusman, D. Sajuthi, O. Kalliokoski, K. R. Jacobsen, J. Call, S. J. Schapiro, A. Gjedde, K. S.P. Abelson, J. Hau

Research output: Contribution to journalArticle

Abstract

Background: In an attempt to explore cynomolgus monkeys as an animal model for Alzheimer's disease, the present study focused on the Alzheimer's biomarkers beta amyloid 1-42 (Aβ42) in serum, and total tau (t-tau) and phosphorylated tau (p-tau) levels in cerebrospinal fluid. Methods: We measured biomarker levels in Young and Aged cynomolgus monkeys and correlated these with performance on three delayed response tasks. Results: The Aβ42 concentration of the Aged monkeys was significantly lower than in the Young subjects, while the t-tau and p-tau did not significantly differ between the groups. The Young subjects performed significantly better than the Aged individuals on the memory tests. Only Aβ42 levels were significantly correlated with performance in the three delayed response tasks. Conclusions: Circulating Aβ42 levels were lower in Aged monkeys and were correlated with inferior performance on delayed response tasks in Aged animals; therefore, both measures may be useful in establishing cynomolgus monkeys as models for studies of AD.

Original languageEnglish (US)
Pages (from-to)137-146
Number of pages10
JournalJournal of medical primatology
Volume42
Issue number3
DOIs
StatePublished - Jun 2013

Keywords

  • Aging
  • Alzheimer's disease
  • Biomarker
  • Memory test

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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