Correlations between sample morphology and MALDI-TOF MS signal characteristics

A. Feldman, M. Antoine, P. Demirev, J. Lin

Research output: Contribution to conferencePaper

Abstract

The potential for using quantitative characteristics calculated from digital microscopic images of samples to predict 'hot spots' locations in order to guide MALDI signal acquisition was analyzed. Initial studies of MALDI signal correlations were performed with data obtained on a Kompact MALDI Discovery instrument with one-dimensional (1D) rastering capability. The angiotensin peak area for each trace was estimated and the spatial autocorrelation function of the signal was computed. The results suggest that strategies for performing optimal signal fusion based on visual surface features should be pursued with caution and that 'hot spot' locations for one ion species will not necessarily correspond to those for other ion species.

Original languageEnglish (US)
Pages35-36
Number of pages2
StatePublished - Dec 1 2002
EventProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States
Duration: Jun 2 2002Jun 6 2002

Other

OtherProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
CountryUnited States
CityOrlando, FL
Period6/2/026/6/02

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ASJC Scopus subject areas

  • Spectroscopy

Cite this

Feldman, A., Antoine, M., Demirev, P., & Lin, J. (2002). Correlations between sample morphology and MALDI-TOF MS signal characteristics. 35-36. Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States.