TY - JOUR
T1 - Correlation of Viral Loads with HCV Genotypes
T2 - Higher Levels of Virus Were Revealed among Blood Donors Infected with 6a Strains
AU - Rong, Xia
AU - Lu, Ling
AU - Wang, Junzhi
AU - Xiong, Huaping
AU - Huang, Jieting
AU - Chen, Jinyan
AU - Huang, Ke
AU - Xu, Ru
AU - Wang, Min
AU - Zhang, Xuemei
AU - Guo, Tai
AU - Liu, Yueyue
AU - Gao, Guoquan
AU - Fu, Yongshui
AU - Nelson, Kenrad E.
PY - 2012/12/17
Y1 - 2012/12/17
N2 - Background: Both HCV genotypes and viral loads are predictors of therapeutic outcomes among patients treated with α-interferon plus ribavirin; however, such correlation has only been studied for genotypes 1, 2, and 3 but not for genotype 6. Methodology/Findings: 299 voluntary blood donors were recruited who were HCV viremic. Their mean age was 31.8; the male/female ratio was 3.82 (225/59). The viral loads of HCV were measured using the COBAS AmpliPrep/COBAS TaqMan test (CAP/CTM) while HCV genotypes were determined by direct sequencing the partial NS5B region. HCV genotypes 1, 2, 3, and 6 were determined in 48.9%, 8.7%, 12.3%, and 30.1% of the donors, respectively, and the levels of mean viral loads in genotype 1 and 6 significantly higher than that of 2 and 3 (P<0.001). As a whole, the viral loads in male donors were higher than in female (P = 0.006). Moreover, the donors' gender and HCV genotypes are independently correlated with the measured viral loads. Conclusion: HCV genotype 1 and 6 had significantly higher viral loads than genotype 2 and 3.
AB - Background: Both HCV genotypes and viral loads are predictors of therapeutic outcomes among patients treated with α-interferon plus ribavirin; however, such correlation has only been studied for genotypes 1, 2, and 3 but not for genotype 6. Methodology/Findings: 299 voluntary blood donors were recruited who were HCV viremic. Their mean age was 31.8; the male/female ratio was 3.82 (225/59). The viral loads of HCV were measured using the COBAS AmpliPrep/COBAS TaqMan test (CAP/CTM) while HCV genotypes were determined by direct sequencing the partial NS5B region. HCV genotypes 1, 2, 3, and 6 were determined in 48.9%, 8.7%, 12.3%, and 30.1% of the donors, respectively, and the levels of mean viral loads in genotype 1 and 6 significantly higher than that of 2 and 3 (P<0.001). As a whole, the viral loads in male donors were higher than in female (P = 0.006). Moreover, the donors' gender and HCV genotypes are independently correlated with the measured viral loads. Conclusion: HCV genotype 1 and 6 had significantly higher viral loads than genotype 2 and 3.
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U2 - 10.1371/journal.pone.0052467
DO - 10.1371/journal.pone.0052467
M3 - Article
C2 - 23285053
AN - SCOPUS:84871322483
SN - 1932-6203
VL - 7
JO - PLoS One
JF - PLoS One
IS - 12
M1 - e52467
ER -