TY - JOUR
T1 - Correlation of transconjunctival PO2 with cerebral oxygen delivery during cardiopulmonary resuscitation in dogs
AU - Guerci, A. D.
AU - Thomas, K.
AU - Hess, D.
AU - Halperin, H. R.
AU - Tsitlik, J. E.
AU - Wurmb, E.
AU - Eitel, D.
PY - 1988
Y1 - 1988
N2 - The relationship between transconjunctival PO2 (PcjO2) and cerebral oxygen delivery (ḊO2) was examined in dogs during sinus rhythm and CPR with an inflatable vest. Microsphere-determined cerebral blood flow (CBF), ḊO2, and PcjO2 readings were normal during sinus rhythm. During CPR, with carotid pressure of 82 ± 11/25 ± 5 (SEM) mm Hg, cerebral perfusion and ḊO2 fell by 53% and 57%, respectively, while PcjO2 fell by 87%. After epinephrine administration, carotid pressure increased to 128 ± 13/48 ± 9 mm Hg, and CBF and ḊO2 rose to 130% and 115% of pre-arrest levels, respectively, but PcjO2 readings remained at 11% of control values. Thus, PcjO2 failed to reflect accurately either CBF or ḊO2 during CPR. In the presence of epinephrine, PcjO2 does not seem to provide an accurate index of the effectiveness of CPR.
AB - The relationship between transconjunctival PO2 (PcjO2) and cerebral oxygen delivery (ḊO2) was examined in dogs during sinus rhythm and CPR with an inflatable vest. Microsphere-determined cerebral blood flow (CBF), ḊO2, and PcjO2 readings were normal during sinus rhythm. During CPR, with carotid pressure of 82 ± 11/25 ± 5 (SEM) mm Hg, cerebral perfusion and ḊO2 fell by 53% and 57%, respectively, while PcjO2 fell by 87%. After epinephrine administration, carotid pressure increased to 128 ± 13/48 ± 9 mm Hg, and CBF and ḊO2 rose to 130% and 115% of pre-arrest levels, respectively, but PcjO2 readings remained at 11% of control values. Thus, PcjO2 failed to reflect accurately either CBF or ḊO2 during CPR. In the presence of epinephrine, PcjO2 does not seem to provide an accurate index of the effectiveness of CPR.
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U2 - 10.1097/00003246-198806000-00010
DO - 10.1097/00003246-198806000-00010
M3 - Article
C2 - 3371026
AN - SCOPUS:0023820432
SN - 0090-3493
VL - 16
SP - 612
EP - 614
JO - Critical care medicine
JF - Critical care medicine
IS - 6
ER -