TY - JOUR
T1 - Correlation of reaction time in and out of the functional MR unit
AU - Mikhelashvili-Browner, Nina
AU - Yousem, David M.
AU - Mandir, Allen S.
AU - Calhoun, Vince D.
AU - Wu, Colin
AU - Oguz, Kader Karli
AU - Vaughan, Christina L.
N1 - Funding Information:
Supported by the Joint Committee on Clinical Investigations of Johns Hopkins School of Medicine grant RPN 99-10-29-04.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2002
Y1 - 2002
N2 - Rationale and Objectives. The authors performed this study to determine whether reaction times (RTs) recorded in the functional magnetic resonance (MR) imaging environment reflect the performance of the patient outside the imaging room. Materials and Methods. Fifteen healthy control subjects (mean age, 61.6 years) performed a simple reaction time (SRT) task outside the MR magnet and a visuomotor response time task inside the magnet with use of block-design and event-related paradigms. For both behavioral and functional MR imaging tests, subjects tapped the right index finger upon the appearance of a visual cue. The mean RTs for out-of-magnet and functional MR imaging paradigms were compared. Results. There was a statistically significant difference in RTs between block-design and single-event paradigms (t = 3.458, P < .004). The RT values during functional MR imaging and SRT tasks did not show significant differences (.65 < P < .7, paired t test). However, no correlation was found in RT values between event-related (p = -0.004, P = .15) or block-design (p = 0.03, P = .13) paradigms and SRT data. With the block-design functional MR imaging paradigm, the RT was significantly faster (P < .0003) at the beginning of the session than the end, illustrating the effect of anticipation. Conclusion. Functional MR imaging RTs must be used to determine the correlation between subjects' performance and the volume of brain activation in a functional MR imaging experiment. The effect of anticipation should be minimized, which could best be achieved by using event-related paradigms.
AB - Rationale and Objectives. The authors performed this study to determine whether reaction times (RTs) recorded in the functional magnetic resonance (MR) imaging environment reflect the performance of the patient outside the imaging room. Materials and Methods. Fifteen healthy control subjects (mean age, 61.6 years) performed a simple reaction time (SRT) task outside the MR magnet and a visuomotor response time task inside the magnet with use of block-design and event-related paradigms. For both behavioral and functional MR imaging tests, subjects tapped the right index finger upon the appearance of a visual cue. The mean RTs for out-of-magnet and functional MR imaging paradigms were compared. Results. There was a statistically significant difference in RTs between block-design and single-event paradigms (t = 3.458, P < .004). The RT values during functional MR imaging and SRT tasks did not show significant differences (.65 < P < .7, paired t test). However, no correlation was found in RT values between event-related (p = -0.004, P = .15) or block-design (p = 0.03, P = .13) paradigms and SRT data. With the block-design functional MR imaging paradigm, the RT was significantly faster (P < .0003) at the beginning of the session than the end, illustrating the effect of anticipation. Conclusion. Functional MR imaging RTs must be used to determine the correlation between subjects' performance and the volume of brain activation in a functional MR imaging experiment. The effect of anticipation should be minimized, which could best be achieved by using event-related paradigms.
KW - Aging
KW - Magnetic resonance (MR), functional imaging
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U2 - 10.1016/S1076-6332(03)80327-6
DO - 10.1016/S1076-6332(03)80327-6
M3 - Article
C2 - 12458876
AN - SCOPUS:0036239326
SN - 1076-6332
VL - 9
SP - 513
EP - 519
JO - Academic radiology
JF - Academic radiology
IS - 5
ER -