Correlation of rapid changes in the average water diffusion constant and the concentrations of lactate and ATP breakdown products during global ischemia in cat brain

Caroline Decanniere, Scott Eleff, Delphine Davis, Peter C.M.Van Zijl

Research output: Contribution to journalArticlepeer-review

Abstract

Rapid changes in the average water diffusion constant, Dav = 1/3{Dxx + Dyy + Dzz}, and in the concentrations of lactate and purine nucleotides and nucleosides were measured upon global ischemia (cardiac arrest) in cat brain, at a combined time resolution of 36 s (n = 7). At this time resolution, the normalized time curves of 1 ‐ Dav and the increases in ATP breakdown products did not coincide, with the changes in Dav being most rapid. The normalized curves of 1 ‐ Dav and the lactate increase coincided for the first 2‐2.5 min after which the change in Dav was more rapid. After this time point, an excellent correlation was found between the drop in Dav and the decrease in energy utilization rate, which was calculated from the measured time curves of lactate formation and ATP breakdown, and from the time curve for phosphocreatine use reported in the literature. These results are in agreement with the expected biphasic changes in ion and water homeostasis during ischemia and with the model of diffusional changes being a consequence of a water shift from interstitial to intra‐cellular space.

Original languageEnglish (US)
Pages (from-to)343-352
Number of pages10
JournalMagnetic resonance in medicine
Volume34
Issue number3
DOIs
StatePublished - Sep 1995

Keywords

  • NMR spectroscopy
  • brain ischemia
  • cardiac arrest
  • water diffusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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