Correlation of preterm infant illness severity with placental histology

Karen M. Chisholm, Amy Heerema-Mckenney, Lu Tian, Anand K. Rajani, Suchi Saria, Daphne Koller, Anna A. Penn

Research output: Contribution to journalArticle

Abstract

Introduction A major goal of neonatal medicine is to identify neonates at highest risk for morbidity and mortality. Previously, we developed PhysiScore (Saria et al., 2010), a novel tool for preterm morbidity risk prediction. We now further define links between overall individual morbidity risk, specific neonatal morbidities, and placental pathologies. Methods 102 placentas, including 38 from multiple gestations, were available from the previously defined PhysiScore cohort (gestational age ≤ 34 weeks and birth weight ≤ 2000 g). Placentas were analyzed for gross and histologic variables including maternal malperfusion, amniotic fluid infection sequence, chronic inflammation, and fetal vascular obstruction. Risk as determined by PhysiScore and recorded neonatal morbidities were tested for statistical association with placental findings. Results In pair-wise correlations, respiratory distress syndrome, bronchopulmonary dysplasia, acute hemodynamic instability, post-hemorrhagic hydrocephalus, culture-positive sepsis, and necrotizing enterocolitis each significantly correlated with at least one placenta histology variable. Amniotic fluid infection sequence (p = 0.039), specifically the fetal inflammatory response (p = 0.017), correlated with higher PhysiScores (greater morbidity) but was not independent of gestational age and birth weight. In multivariate analyses correlating variables with all nine morbidities, gestational age (p <0.001), placental size

Original languageEnglish (US)
Pages (from-to)61-69
Number of pages9
JournalPlacenta
Volume39
DOIs
StatePublished - Mar 1 2016

Fingerprint

Premature Infants
Histology
Morbidity
Placenta
Gestational Age
Amniotic Fluid
Birth Weight
Bronchopulmonary Dysplasia
Necrotizing Enterocolitis
Hydrocephalus
Infection
Blood Vessels
Sepsis
Multivariate Analysis
Hemodynamics
Mothers
Medicine
Newborn Infant
Pathology
Inflammation

Keywords

  • Fetal inflammatory response
  • Histology
  • Morbidity
  • Placenta
  • Preterm infant

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine
  • Developmental Biology

Cite this

Chisholm, K. M., Heerema-Mckenney, A., Tian, L., Rajani, A. K., Saria, S., Koller, D., & Penn, A. A. (2016). Correlation of preterm infant illness severity with placental histology. Placenta, 39, 61-69. https://doi.org/10.1016/j.placenta.2016.01.012

Correlation of preterm infant illness severity with placental histology. / Chisholm, Karen M.; Heerema-Mckenney, Amy; Tian, Lu; Rajani, Anand K.; Saria, Suchi; Koller, Daphne; Penn, Anna A.

In: Placenta, Vol. 39, 01.03.2016, p. 61-69.

Research output: Contribution to journalArticle

Chisholm, KM, Heerema-Mckenney, A, Tian, L, Rajani, AK, Saria, S, Koller, D & Penn, AA 2016, 'Correlation of preterm infant illness severity with placental histology', Placenta, vol. 39, pp. 61-69. https://doi.org/10.1016/j.placenta.2016.01.012
Chisholm KM, Heerema-Mckenney A, Tian L, Rajani AK, Saria S, Koller D et al. Correlation of preterm infant illness severity with placental histology. Placenta. 2016 Mar 1;39:61-69. https://doi.org/10.1016/j.placenta.2016.01.012
Chisholm, Karen M. ; Heerema-Mckenney, Amy ; Tian, Lu ; Rajani, Anand K. ; Saria, Suchi ; Koller, Daphne ; Penn, Anna A. / Correlation of preterm infant illness severity with placental histology. In: Placenta. 2016 ; Vol. 39. pp. 61-69.
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