Abstract
Introduction A major goal of neonatal medicine is to identify neonates at highest risk for morbidity and mortality. Previously, we developed PhysiScore (Saria et al., 2010), a novel tool for preterm morbidity risk prediction. We now further define links between overall individual morbidity risk, specific neonatal morbidities, and placental pathologies. Methods 102 placentas, including 38 from multiple gestations, were available from the previously defined PhysiScore cohort (gestational age ≤ 34 weeks and birth weight ≤ 2000 g). Placentas were analyzed for gross and histologic variables including maternal malperfusion, amniotic fluid infection sequence, chronic inflammation, and fetal vascular obstruction. Risk as determined by PhysiScore and recorded neonatal morbidities were tested for statistical association with placental findings. Results In pair-wise correlations, respiratory distress syndrome, bronchopulmonary dysplasia, acute hemodynamic instability, post-hemorrhagic hydrocephalus, culture-positive sepsis, and necrotizing enterocolitis each significantly correlated with at least one placenta histology variable. Amniotic fluid infection sequence (p = 0.039), specifically the fetal inflammatory response (p = 0.017), correlated with higher PhysiScores (greater morbidity) but was not independent of gestational age and birth weight. In multivariate analyses correlating variables with all nine morbidities, gestational age (p <0.001), placental size
| Original language | English (US) |
|---|---|
| Pages (from-to) | 61-69 |
| Number of pages | 9 |
| Journal | Placenta |
| Volume | 39 |
| DOIs | |
| State | Published - Mar 1 2016 |
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Keywords
- Fetal inflammatory response
- Histology
- Morbidity
- Placenta
- Preterm infant
ASJC Scopus subject areas
- Obstetrics and Gynecology
- Reproductive Medicine
- Developmental Biology
Cite this
Correlation of preterm infant illness severity with placental histology. / Chisholm, Karen M.; Heerema-Mckenney, Amy; Tian, Lu; Rajani, Anand K.; Saria, Suchi; Koller, Daphne; Penn, Anna A.
In: Placenta, Vol. 39, 01.03.2016, p. 61-69.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Correlation of preterm infant illness severity with placental histology
AU - Chisholm, Karen M.
AU - Heerema-Mckenney, Amy
AU - Tian, Lu
AU - Rajani, Anand K.
AU - Saria, Suchi
AU - Koller, Daphne
AU - Penn, Anna A.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Introduction A major goal of neonatal medicine is to identify neonates at highest risk for morbidity and mortality. Previously, we developed PhysiScore (Saria et al., 2010), a novel tool for preterm morbidity risk prediction. We now further define links between overall individual morbidity risk, specific neonatal morbidities, and placental pathologies. Methods 102 placentas, including 38 from multiple gestations, were available from the previously defined PhysiScore cohort (gestational age ≤ 34 weeks and birth weight ≤ 2000 g). Placentas were analyzed for gross and histologic variables including maternal malperfusion, amniotic fluid infection sequence, chronic inflammation, and fetal vascular obstruction. Risk as determined by PhysiScore and recorded neonatal morbidities were tested for statistical association with placental findings. Results In pair-wise correlations, respiratory distress syndrome, bronchopulmonary dysplasia, acute hemodynamic instability, post-hemorrhagic hydrocephalus, culture-positive sepsis, and necrotizing enterocolitis each significantly correlated with at least one placenta histology variable. Amniotic fluid infection sequence (p = 0.039), specifically the fetal inflammatory response (p = 0.017), correlated with higher PhysiScores (greater morbidity) but was not independent of gestational age and birth weight. In multivariate analyses correlating variables with all nine morbidities, gestational age (p <0.001), placental size
AB - Introduction A major goal of neonatal medicine is to identify neonates at highest risk for morbidity and mortality. Previously, we developed PhysiScore (Saria et al., 2010), a novel tool for preterm morbidity risk prediction. We now further define links between overall individual morbidity risk, specific neonatal morbidities, and placental pathologies. Methods 102 placentas, including 38 from multiple gestations, were available from the previously defined PhysiScore cohort (gestational age ≤ 34 weeks and birth weight ≤ 2000 g). Placentas were analyzed for gross and histologic variables including maternal malperfusion, amniotic fluid infection sequence, chronic inflammation, and fetal vascular obstruction. Risk as determined by PhysiScore and recorded neonatal morbidities were tested for statistical association with placental findings. Results In pair-wise correlations, respiratory distress syndrome, bronchopulmonary dysplasia, acute hemodynamic instability, post-hemorrhagic hydrocephalus, culture-positive sepsis, and necrotizing enterocolitis each significantly correlated with at least one placenta histology variable. Amniotic fluid infection sequence (p = 0.039), specifically the fetal inflammatory response (p = 0.017), correlated with higher PhysiScores (greater morbidity) but was not independent of gestational age and birth weight. In multivariate analyses correlating variables with all nine morbidities, gestational age (p <0.001), placental size
KW - Fetal inflammatory response
KW - Histology
KW - Morbidity
KW - Placenta
KW - Preterm infant
UR - http://www.scopus.com/inward/record.url?scp=84960855341&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84960855341&partnerID=8YFLogxK
U2 - 10.1016/j.placenta.2016.01.012
DO - 10.1016/j.placenta.2016.01.012
M3 - Article
C2 - 26992676
AN - SCOPUS:84960855341
VL - 39
SP - 61
EP - 69
JO - Placenta
JF - Placenta
SN - 0143-4004
ER -