Correlation of measures of regional lung ventilation from 4DCT vs. hyperpolarized helium-3 MR

Kai Ding, Kunlin Cao, Wilson Miller, Gary Christensen, Joseph Reinhardt, Stanley Benedict, Bruce Libby, Ke Sheng

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Radiation induced pulmonary diseases can change the tissue material properties of lung parenchyma and the mechanics of the respiratory system. Recent advances in multi-detector-row CT (MDCT), 4DCT respiratory gating methods, and image processing techniques enable us to follow and measure those changes noninvasively during radiation therapy at a regional level. This study compares the 4DCT based ventilation measurement with the results from hyperpolarized helium-3 MR using the cumulative distribution function maps and the relative overlap (RO) statistic. We show that the similarity between the two measurements increases as the increase of the B-Spline grid spacing and Laplacian weighting which result a smoother ventilation map. The best similarity is found with weighting of 0.5 for linear elasticity and B-Spline grid spacing of 32 mm. Future work is to improve the lung image registration algorithm by incorporating hyperpolarized helium-3 MR information so as to improve its physiological modeling of the lung tissue deformation.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging
Volume8317
DOIs
Publication statusPublished - 2012
Externally publishedYes
EventMedical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging - San Diego, CA, United States
Duration: Feb 5 2012Feb 7 2012

Other

OtherMedical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CitySan Diego, CA
Period2/5/122/7/12

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Keywords

  • 4DCT
  • Image registration
  • MRI
  • Pulmonary
  • Ventilation

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Ding, K., Cao, K., Miller, W., Christensen, G., Reinhardt, J., Benedict, S., ... Sheng, K. (2012). Correlation of measures of regional lung ventilation from 4DCT vs. hyperpolarized helium-3 MR. In Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging (Vol. 8317). [83171E] https://doi.org/10.1117/12.912793