Correlation of intestinal lactulose permeability with exocrine pancreatic dysfunction

David R. Mack, Jonathan A. Flick, Peter R. Durie, Beryl J Rosenstein, Lynda E. Ellis, Jay A. Perman

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Increased intestinal permeability to lactulose has been reported in patients with cystic fibrosis (CF). To determine whether this finding is unique to CF or whether it is related to accompanying exocrine pancreatic dysfunction, we evaluated 31 patients with CF and 10 with Shwachman syndrome who had variable degrees of pancreatic dysfunction, together with 17 healthy control subjects. There was no significant difference in the mean urinary lactulose excretion, expressed as the percentage of dose recovered, between CF and non-CF patients with pancreatic insufficiency (2.1%±1.2% and 1.9%±0.8%, respectively) or between CF and non-CF patients with pancreatic sufficiency (0.6%±0.5% and 0.6%±0.3%, respectively). However, there was a significant difference in mean lactulose excretion between the pancreatic-insufficient and the pancreatic-sufficient patients (both CF and non-CF groups; p

Original languageEnglish (US)
Pages (from-to)696-701
Number of pages6
JournalJournal of Pediatrics
Issue number5
Publication statusPublished - 1992


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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