Correlation of interleukin-10 gene haplotype with hepatocellular carcinoma in Taiwan

L. H. Tseng, Ming-Tseh Lin, W. Y. Shau, W. C. Lin, F. Y. Chang, K. L. Chien, J. A. Hansen, D. S. Chen, P. J. Chen

Research output: Contribution to journalArticle

Abstract

Polymorphisms in cytokine genes can influence immune responses, inflammation and tissue injury, and may affect the outcome of hepatitis B virus (HBV) infection. We analyzed single nucleotide polymorphisms (SNP) in the interleukin (IL)-10 gene among 344 HBV carriers and 208 patients with hepatocellular carcinoma (HCC). Genotypes and haplotypes were tested for association with HCC. IL-10/-592 C/C genotype was associated with a higher risk for HCC compared with IL-10/-592 A/C and A/A genotypes [odds ratio (OR): 2.1, 95% confidence interval (CI): 1.2-3.6]. IL-10/1927 A/A genotype was also associated with a higher risk for HCC compared with IL-10/1927 A/C and C/C genotypes (OR: 1.5, 95% CI: 1.0-2.2). Haplotype analysis revealed that the homozygosity of the C-A haplotype (defined by SNPs at positions -592 and 1927) of IL-10 gene conveys the highest risk for HCC among HBV carriers compared with the homozygosity for the A-C haplotype (OR: 2.6, 95% CI: 1.3-4.9). The results demonstrate that IL-10 gene polymorphism can affect the outcome of chronic HBV infection. Further studies are necessary to clarify how variation in the IL-10 gene affects IL-10 function and risk of HCC.

Original languageEnglish (US)
Pages (from-to)127-133
Number of pages7
JournalTissue Antigens
Volume67
Issue number2
DOIs
StatePublished - 2006
Externally publishedYes

Keywords

  • Hepatitis B virus
  • Hepatocellular carcinoma
  • IL-10
  • Polymorphism

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Genetics

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  • Cite this

    Tseng, L. H., Lin, M-T., Shau, W. Y., Lin, W. C., Chang, F. Y., Chien, K. L., Hansen, J. A., Chen, D. S., & Chen, P. J. (2006). Correlation of interleukin-10 gene haplotype with hepatocellular carcinoma in Taiwan. Tissue Antigens, 67(2), 127-133. https://doi.org/10.1111/j.1399-0039.2006.00536.x