Correlation of interleukin-10 gene haplotype with hepatocellular carcinoma in Taiwan

L. H. Tseng, M. T. Lin, W. Y. Shau, W. C. Lin, F. Y. Chang, K. L. Chien, J. A. Hansen, D. S. Chen, P. J. Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Polymorphisms in cytokine genes can influence immune responses, inflammation and tissue injury, and may affect the outcome of hepatitis B virus (HBV) infection. We analyzed single nucleotide polymorphisms (SNP) in the interleukin (IL)-10 gene among 344 HBV carriers and 208 patients with hepatocellular carcinoma (HCC). Genotypes and haplotypes were tested for association with HCC. IL-10/-592 C/C genotype was associated with a higher risk for HCC compared with IL-10/-592 A/C and A/A genotypes [odds ratio (OR): 2.1, 95% confidence interval (CI): 1.2-3.6]. IL-10/1927 A/A genotype was also associated with a higher risk for HCC compared with IL-10/1927 A/C and C/C genotypes (OR: 1.5, 95% CI: 1.0-2.2). Haplotype analysis revealed that the homozygosity of the C-A haplotype (defined by SNPs at positions -592 and 1927) of IL-10 gene conveys the highest risk for HCC among HBV carriers compared with the homozygosity for the A-C haplotype (OR: 2.6, 95% CI: 1.3-4.9). The results demonstrate that IL-10 gene polymorphism can affect the outcome of chronic HBV infection. Further studies are necessary to clarify how variation in the IL-10 gene affects IL-10 function and risk of HCC.

Original languageEnglish (US)
Pages (from-to)127-133
Number of pages7
JournalTissue Antigens
Volume67
Issue number2
DOIs
StatePublished - Feb 2006
Externally publishedYes

Keywords

  • Hepatitis B virus
  • Hepatocellular carcinoma
  • IL-10
  • Polymorphism

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

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