Correlation of interferon-γ production by peripheral blood mononuclear cells with childhood malnutrition and susceptibility to amebiasis

Rashidul Haque, Dinesh Mondal, Jianfen Shu, Shantanu Roy, Mamun Kabir, Andrea N. Davis, Priya Duggal, William A. Petri

Research output: Contribution to journalArticle

Abstract

The contribution of interferon-γ (IFN-γ) to immunity from amebiasis was assessed in a three-year prospective study of children 2-5 years of age in an urban slum of Dhaka, Bangladesh. IFN-γ produced by peripheral blood mononuclear cells stimulated with soluble amebic antigen was measured upon enrollment. Thirty-one of the 209 enrolled children had Entamoeba histolytica-associated diarrhea. Children who produced higher than the median level of IFN-γ (median = 580 pg/mL) had longer survival without E. histolytica diarrhea/dysentery (log rank test P = 0.03) and a reduction in the risk of E. histolytica diarrhea/dysentery by more than half (Cox proportional hazard regression = 0.45, P = 0.04). When adjusted for stunting, the association between IFN-γ and the time to the first episode of E. histolytica-associated diarrhea remained marginally significant (Cox proportional hazard regression = 0.49, P = 0.07). We conclude that production of IFN-γ is linked to nutritional status and predicts future susceptibility to symptomatic amebiasis.

Original languageEnglish (US)
Pages (from-to)340-344
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume76
Issue number2
StatePublished - Feb 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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