Abstract
Purpose: We aim to correlate size and shape of corpus callosum with severity of motor and cognitive impairments in children with periventricular leukomalacia (PVL). Methods: Children with PVL were stratified based on the severity of their motor and cognitive impairments. An age-matched control group was established. The corpus callosum was identified on mid-sagittal T 1-weighted spin-echo (TR/TE: 550/15) MR images. The shape characteristics of the corpus callosum were measured with respect to a template via a shape transformation. The degree of callosal-shape transformation was quantified by a deformation function, which in turn was compared, using point-wise t-tests, for controls versus patients, diplegic versus quadriplegic patients, and patients with mild versus severe cognitive impairment. Results: 29 children with spastic cerebral palsy and PVL and 32 age-matched controls were identified. In the PVL group, the entire corpus callosum was significantly smaller than in the control group (p value = 0.001). Significant differences existed in the shape of the corpus callosum between patients with diplegic versus quadriplegic and between patients with severe versus mild cognitive impairment. Conclusion: Global and regional corpus callosal morphology can be quantified using deformation functions.
Original language | English (US) |
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Pages (from-to) | 247-252 |
Number of pages | 6 |
Journal | Neuropediatrics |
Volume | 34 |
Issue number | 5 |
DOIs | |
State | Published - Oct 2003 |
Externally published | Yes |
Keywords
- Cerebral palsy
- Cognitive function
- Corpus callosum
- Morphometry
- Motorfunction
- Periventricular leukomalacia
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Clinical Neurology