Correlation of apparent diffusion coefficient with Ki-67 proliferation index in grading meningioma

Yi Tang, Sathish K. Dundamadappa, Senthur Thangasamy, Thomas Flood, Richard Moser, Thomas Smith, Keith Cauley, Deepak Takhtani

Research output: Contribution to journalArticlepeer-review


OBJECTIVE. A noninvasive method to predict aggressiveness of high-grade meningiomas would be desirable because it would help anticipate tumor recurrence and improve tumor management and the treatment outcomes. The Ki-67 protein is a marker of tumor proliferation, and apparent diffusion coefficient (ADC) is related to tumor cellularity. Therefore, we sought to determine whether there is a statistically significant correlation between ADC and Ki-67 values in meningiomas and whether ADC values can differentiate various meningioma subtypes. MATERIALS AND METHODS. MRI examinations and histopathology of 68 surgically treated meningiomas were retrospectively reviewed. Mean ADC values were derived from diffusion imaging. Correlation coefficients were calculated for mean ADC and Ki-67 proliferation index values using linear regression. An independent unpaired Student t test was used to compare the ADC and Ki-67 proliferation index values from low-grade and more aggressive RESULTS. A statistically significant inverse correlation was found between ADC and Ki-67 proliferation index for low-grade and aggressive meningiomas (r 2=-0.33, p = 0.0039). ADC values (± SD) of low-grade meningiomas (0.84 ± 0.14 × 10-3 mm2/s) and aggressive (atypical or anaplastic) meningiomas (0.75 ± 0.03 × 10-3 mm2/s) were significantly different (p = 0.0495). Using an ADC cutoff value of 0.70 × 10-3 mm2/s, the sensitivity for diagnosing aggressive meningiomas was 29%, specificity was 94%, positive predictive value was 67%, and negative predictive value was 75%. CONCLUSION. ADC values correlate inversely with Ki-67 proliferation index and help differentiate low-grade from aggressive meningiomas. meningiomas.

Original languageEnglish (US)
Pages (from-to)1303-1308
Number of pages6
JournalAmerican Journal of Roentgenology
Issue number6
StatePublished - Jun 2014


  • Apparent diffusion coefficient
  • Diffusion-weighted imaging
  • Ki-67
  • Meningioma grading
  • Prognosis
  • Recurrence

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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