Correlation of acute cocaine-induced changes in local cerebral blood flow with subjective effects

Godfrey D. Pearlson; Petra J. Jeffery; Gordon J. Harris; Christopher A. Ross; Marian W. Fischman; Edwaldo E. Camargo

doi:10.1176/ajp.150.3.495

Correlation of acute cocaine-induced changes in local cerebral blood flow with subjective effects

Godfrey D. Pearlson, Petra J. Jeffery, Gordon J. Harris, Christopher A. Ross, Marian W. Fischman, Edwaldo E. Camargo

Research output: Contribution to journal › Article › peer-review

Abstract

The authors administered 48 mg of intravenous cocaine or placebo to eight abstinent cocaine users in a double-blind, crossover design and examined blood flow using single photon emission computed tomography. Cocaine produced significant decreases in frontal cortical and basal ganglia blood flow, these latter correlated negatively with increases in self-ratings of "rush" and "high." The authors conclude that these local effects are compatible with dopaminergic system involvement.

Original language	English (US)
Pages (from-to)	495-497
Number of pages	3
Journal	American Journal of Psychiatry
Volume	150
Issue number	3
DOIs	https://doi.org/10.1176/ajp.150.3.495
State	Published - Jan 1 1993

ASJC Scopus subject areas

Psychiatry and Mental health

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10.1176/ajp.150.3.495

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AU - Fischman, Marian W.

AU - Camargo, Edwaldo E.

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Correlation of acute cocaine-induced changes in local cerebral blood flow with subjective effects

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