Correlation Between White Matter Injury Identified by Neonatal Diffusion Tensor Imaging and Neurodevelopmental Outcomes Following Term Neonatal Asphyxia and Therapeutic Hypothermia: An Exploratory Pilot Study

Gwendolyn J. Gerner, Eric I. Newman, V. Joanna Burton, Brenton Roman, Elizabeth A. Cristofalo, Mary Leppert, Michael V. Johnston, Frances J. Northington, Thierry A.G.M. Huisman, Andrea Poretti

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: Hypoxic-ischemic encephalopathy is associated with damage to deep gray matter; however, white matter involvement has become recognized. This study explored differences between patients and clinical controls on diffusion tensor imaging, and relationships between diffusion tensor imaging and neurodevelopmental outcomes. Method: Diffusion tensor imaging was obtained for 31 neonates after hypoxic-ischemic encephalopathy treated with therapeutic hypothermia and 10 clinical controls. A subgroup of patients with hypoxic-ischemic encephalopathy (n = 14) had neurodevelopmental outcomes correlated with diffusion tensor imaging scalars. Results: Group differences in diffusion tensor imaging scalars were observed in the putamen, anterior and posterior centrum semiovale, and the splenium of the corpus callosum. Differences in these regions of interest were correlated with neurodevelopmental outcomes between ages 20 and 32 months. Conclusion: Therapeutic hypothermia may not be a complete intervention for hypoxic-ischemic encephalopathy, as neonatal white matter changes may continue to be evident, but further research is warranted. Patterns of white matter change on neonatal diffusion tensor imaging correlated with neurodevelopmental outcomes in this exploratory pilot study.

Original languageEnglish (US)
Pages (from-to)556-566
Number of pages11
JournalJournal of child neurology
Volume34
Issue number10
DOIs
StatePublished - Sep 1 2019

Keywords

  • diffusion tensor imaging
  • hypoxic-ischemic encephalopathy
  • infant
  • neurodevelopment
  • outcome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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