TY - JOUR
T1 - Correlation between testosterone and the inflammatory marker soluble interleukin-6 receptor in older men
AU - Maggio, Marcello
AU - Basaria, Shehzad
AU - Ble, Alessandro
AU - Lauretani, Fulvio
AU - Bandinelli, Stefania
AU - Ceda, Gian Paolo
AU - Valenti, Giorgio
AU - Ling, Shari M.
AU - Ferrucci, Luigi
PY - 2006/1
Y1 - 2006/1
N2 - Context: An age-associated decline in testosterone (T) levels and an increase in proinflammatory cytokines contribute to chronic diseases in older men. Whether and how these changes are related is unclear. Objective: We hypothesized that T and inflammatory markers are negatively correlated in older men. Design: This was a cross-sectional study. Setting: A population-based sample of older men was studied. Participants and Measures: After excluding participants taking glucocorticoids or antibiotics or those with recent hospitalization, 467 men, aged 65 yr or older, had complete determinations of total T, bioavailable T, SHBG, albumin, IL-6, soluble IL-6 receptor (sIL-6r), TNF-α, IL-1β, and C-reactive protein. Results: After adjusting for potential confounders, sIL-6r was significantly and inversely correlated with total T (r = -0.20; P < 0.001) and bioavailable T (r = -0.12; P < 0.05). T was not correlated with any other inflammatory marker. Conclusions: These preliminary findings suggest an inverse relationship between T and sIL-6r. Longitudinal studies are needed to establish the causality of this association.
AB - Context: An age-associated decline in testosterone (T) levels and an increase in proinflammatory cytokines contribute to chronic diseases in older men. Whether and how these changes are related is unclear. Objective: We hypothesized that T and inflammatory markers are negatively correlated in older men. Design: This was a cross-sectional study. Setting: A population-based sample of older men was studied. Participants and Measures: After excluding participants taking glucocorticoids or antibiotics or those with recent hospitalization, 467 men, aged 65 yr or older, had complete determinations of total T, bioavailable T, SHBG, albumin, IL-6, soluble IL-6 receptor (sIL-6r), TNF-α, IL-1β, and C-reactive protein. Results: After adjusting for potential confounders, sIL-6r was significantly and inversely correlated with total T (r = -0.20; P < 0.001) and bioavailable T (r = -0.12; P < 0.05). T was not correlated with any other inflammatory marker. Conclusions: These preliminary findings suggest an inverse relationship between T and sIL-6r. Longitudinal studies are needed to establish the causality of this association.
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U2 - 10.1210/jc.2005-1097
DO - 10.1210/jc.2005-1097
M3 - Article
C2 - 16263825
AN - SCOPUS:30344449759
SN - 0021-972X
VL - 91
SP - 345
EP - 347
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 1
ER -