Correlation between REM AHI and quality-of-life scores in children with sleep-disordered breathing

Cristina Marie Baldassari, Lyla Alam, Maria Vigilar, James Benke, Charley Martin, Stacey Ishman

Research output: Contribution to journalArticle

Abstract

Objectives. Prior research has demonstrated poor correlation between the obstructive apnea-hypopnea index (AHI) on full-night polysomnogram (PSG) and quality-of-life (QOL) scores. We aim to examine the association between rapid eye movement (REM) AHI and QOL scores in children with sleep-disordered breathing (SDB).

Study Design. Prospective trial.

Setting. Two tertiary childrens hospitals.

Subjects and Methods. Children between 3 and 16 years of age with suspected SDB who were undergoing PSG were eligible. Children with craniofacial anomalies were excluded. Subjects caregivers completed the Obstructive Sleep Apnea18 (OSA-18), a validated QOL survey. Power analysis determined a group size of 34.

Results. One hundred twenty-seven patients were enrolled. The mean (SD) age was 6.3 (3.3) years. Most subjects (52%) were black and 26% were obese. The mean (SD) obstructive AHI of the subject population was 5.4 (11.9), while the mean (SD) REM AHI was 13.1 (23.7). The mean total OSA-18 score was 65.2, indicating a moderate impact of SDB on QOL. Neither the obstructive AHI (P = .73) nor the REM AHI (P = .49) correlated with total OSA-18 scores. However, lower nadir oxygen saturation was associated with significantly poorer QOL (P = .02). The sleep disturbance OSA-18 subset score significantly correlated with both the obstructive AHI (r2 = 0.22; P = .01) and the REM AHI (r2 = 0.22; P = .01); the remaining 4 subset scores did not correlate with either factor.

Conclusion. Neither obstructive AHI nor REM AHI correlates with total OSA-18 QOL scores. With the exception of nadir oxygen saturation, PSG parameters do not reflect the burden of SDB on QOL in children.

Original languageEnglish (US)
Pages (from-to)687-691
Number of pages5
JournalOtolaryngology - Head and Neck Surgery
Volume151
Issue number4
DOIs
StatePublished - Oct 12 2014
Externally publishedYes

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REM Sleep
Sleep Apnea Syndromes
Apnea
Quality of Life
Sleep
Oxygen
Tertiary Care Centers
Caregivers

Keywords

  • obstructive sleep apnea
  • pediatrics
  • polysomnogram
  • quality of life

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery
  • Medicine(all)

Cite this

Correlation between REM AHI and quality-of-life scores in children with sleep-disordered breathing. / Baldassari, Cristina Marie; Alam, Lyla; Vigilar, Maria; Benke, James; Martin, Charley; Ishman, Stacey.

In: Otolaryngology - Head and Neck Surgery, Vol. 151, No. 4, 12.10.2014, p. 687-691.

Research output: Contribution to journalArticle

Baldassari, Cristina Marie ; Alam, Lyla ; Vigilar, Maria ; Benke, James ; Martin, Charley ; Ishman, Stacey. / Correlation between REM AHI and quality-of-life scores in children with sleep-disordered breathing. In: Otolaryngology - Head and Neck Surgery. 2014 ; Vol. 151, No. 4. pp. 687-691.
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abstract = "Objectives. Prior research has demonstrated poor correlation between the obstructive apnea-hypopnea index (AHI) on full-night polysomnogram (PSG) and quality-of-life (QOL) scores. We aim to examine the association between rapid eye movement (REM) AHI and QOL scores in children with sleep-disordered breathing (SDB).Study Design. Prospective trial.Setting. Two tertiary childrens hospitals.Subjects and Methods. Children between 3 and 16 years of age with suspected SDB who were undergoing PSG were eligible. Children with craniofacial anomalies were excluded. Subjects caregivers completed the Obstructive Sleep Apnea18 (OSA-18), a validated QOL survey. Power analysis determined a group size of 34.Results. One hundred twenty-seven patients were enrolled. The mean (SD) age was 6.3 (3.3) years. Most subjects (52{\%}) were black and 26{\%} were obese. The mean (SD) obstructive AHI of the subject population was 5.4 (11.9), while the mean (SD) REM AHI was 13.1 (23.7). The mean total OSA-18 score was 65.2, indicating a moderate impact of SDB on QOL. Neither the obstructive AHI (P = .73) nor the REM AHI (P = .49) correlated with total OSA-18 scores. However, lower nadir oxygen saturation was associated with significantly poorer QOL (P = .02). The sleep disturbance OSA-18 subset score significantly correlated with both the obstructive AHI (r2 = 0.22; P = .01) and the REM AHI (r2 = 0.22; P = .01); the remaining 4 subset scores did not correlate with either factor.Conclusion. Neither obstructive AHI nor REM AHI correlates with total OSA-18 QOL scores. With the exception of nadir oxygen saturation, PSG parameters do not reflect the burden of SDB on QOL in children.",
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T1 - Correlation between REM AHI and quality-of-life scores in children with sleep-disordered breathing

AU - Baldassari, Cristina Marie

AU - Alam, Lyla

AU - Vigilar, Maria

AU - Benke, James

AU - Martin, Charley

AU - Ishman, Stacey

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Y1 - 2014/10/12

N2 - Objectives. Prior research has demonstrated poor correlation between the obstructive apnea-hypopnea index (AHI) on full-night polysomnogram (PSG) and quality-of-life (QOL) scores. We aim to examine the association between rapid eye movement (REM) AHI and QOL scores in children with sleep-disordered breathing (SDB).Study Design. Prospective trial.Setting. Two tertiary childrens hospitals.Subjects and Methods. Children between 3 and 16 years of age with suspected SDB who were undergoing PSG were eligible. Children with craniofacial anomalies were excluded. Subjects caregivers completed the Obstructive Sleep Apnea18 (OSA-18), a validated QOL survey. Power analysis determined a group size of 34.Results. One hundred twenty-seven patients were enrolled. The mean (SD) age was 6.3 (3.3) years. Most subjects (52%) were black and 26% were obese. The mean (SD) obstructive AHI of the subject population was 5.4 (11.9), while the mean (SD) REM AHI was 13.1 (23.7). The mean total OSA-18 score was 65.2, indicating a moderate impact of SDB on QOL. Neither the obstructive AHI (P = .73) nor the REM AHI (P = .49) correlated with total OSA-18 scores. However, lower nadir oxygen saturation was associated with significantly poorer QOL (P = .02). The sleep disturbance OSA-18 subset score significantly correlated with both the obstructive AHI (r2 = 0.22; P = .01) and the REM AHI (r2 = 0.22; P = .01); the remaining 4 subset scores did not correlate with either factor.Conclusion. Neither obstructive AHI nor REM AHI correlates with total OSA-18 QOL scores. With the exception of nadir oxygen saturation, PSG parameters do not reflect the burden of SDB on QOL in children.

AB - Objectives. Prior research has demonstrated poor correlation between the obstructive apnea-hypopnea index (AHI) on full-night polysomnogram (PSG) and quality-of-life (QOL) scores. We aim to examine the association between rapid eye movement (REM) AHI and QOL scores in children with sleep-disordered breathing (SDB).Study Design. Prospective trial.Setting. Two tertiary childrens hospitals.Subjects and Methods. Children between 3 and 16 years of age with suspected SDB who were undergoing PSG were eligible. Children with craniofacial anomalies were excluded. Subjects caregivers completed the Obstructive Sleep Apnea18 (OSA-18), a validated QOL survey. Power analysis determined a group size of 34.Results. One hundred twenty-seven patients were enrolled. The mean (SD) age was 6.3 (3.3) years. Most subjects (52%) were black and 26% were obese. The mean (SD) obstructive AHI of the subject population was 5.4 (11.9), while the mean (SD) REM AHI was 13.1 (23.7). The mean total OSA-18 score was 65.2, indicating a moderate impact of SDB on QOL. Neither the obstructive AHI (P = .73) nor the REM AHI (P = .49) correlated with total OSA-18 scores. However, lower nadir oxygen saturation was associated with significantly poorer QOL (P = .02). The sleep disturbance OSA-18 subset score significantly correlated with both the obstructive AHI (r2 = 0.22; P = .01) and the REM AHI (r2 = 0.22; P = .01); the remaining 4 subset scores did not correlate with either factor.Conclusion. Neither obstructive AHI nor REM AHI correlates with total OSA-18 QOL scores. With the exception of nadir oxygen saturation, PSG parameters do not reflect the burden of SDB on QOL in children.

KW - obstructive sleep apnea

KW - pediatrics

KW - polysomnogram

KW - quality of life

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