Correlation between psychotropic potency of psychotomimetic methoxyamphetamines and their inhibition of 3H-normetanephrine uptake in rat cerebral cortex

Edith D. Hendley, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

THE psychotomimetic methoxyamphetamines are drugs which chemically resemble both mescaline and amphetamine. The subjective effects produced by them are similar to those elicited by other psychotomimetic agents1-3 and cross tolerance has been demonstrated between at least one methoxyamphetamine and mescaline3. There may be some differences in the actions of these drugs and other psychotomimetic agents such as D-lysergic acid diethylamide (LSD), for in clinical trials4-7 and animal tests8 some methoxyamphetamines show considerable amphetamine-like activity, and one of them can produce marked enhancement of self-awareness in the absence of perceptual distortions and disorganization of thinking4-7.

Original languageEnglish (US)
Pages (from-to)264-266
Number of pages3
JournalNature
Volume229
Issue number5282
DOIs
StatePublished - 1971

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Normetanephrine
Amphetamine
Cerebral Cortex
Perceptual Distortion
Mescaline
Hallucinogens
Lysergic Acid Diethylamide
Pharmaceutical Preparations
Inhibition (Psychology)

ASJC Scopus subject areas

  • General

Cite this

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