Correlation between psychotropic potency of psychotomimetic methoxyamphetamines and their inhibition of 3H-normetanephrine uptake in rat cerebral cortex

Edith D. Hendley, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review

Abstract

THE psychotomimetic methoxyamphetamines are drugs which chemically resemble both mescaline and amphetamine. The subjective effects produced by them are similar to those elicited by other psychotomimetic agents1-3 and cross tolerance has been demonstrated between at least one methoxyamphetamine and mescaline3. There may be some differences in the actions of these drugs and other psychotomimetic agents such as D-lysergic acid diethylamide (LSD), for in clinical trials4-7 and animal tests8 some methoxyamphetamines show considerable amphetamine-like activity, and one of them can produce marked enhancement of self-awareness in the absence of perceptual distortions and disorganization of thinking4-7.

Original languageEnglish (US)
Pages (from-to)264-266
Number of pages3
JournalNature
Volume229
Issue number5282
DOIs
StatePublished - Dec 1 1971

ASJC Scopus subject areas

  • General

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