Correlation between prostate volume and single nucleotide polymorphisms implicated in the steroid pathway

Jean Nicolas Cornu, Etienne Audet-Walsh, Sarah Drouin, Pierre Bigot, Antoine Valeri, Georges Fournier, Abdel Rahmène Azzouzi, Morgan Roupret, Luc Cormier, Stephen Chanock, Chantal Guillemette, Olivier Cussenot, Eric Lévesque, Géraldine Cancel-Tassin

Research output: Contribution to journalArticle

Abstract

Objectives: A few preliminary studies have suggested a link between some genetics variants and benign prostatic hyperplasia (BPH). Our goal was to study the link between a set of single nucleotide polymorphisms (SNPs) implicated in the steroid pathway and accurate measurement of prostate volume in a cohort of men who underwent radical prostatectomy. Methods: Clinical and pathological data including prostate weight were obtained from 611 Caucasian patients with small volume, localized prostate cancer treated by radical prostatectomy. Patients were genotyped for 90 SNPs located inside or nearby genes implicated in the steroid pathway (Sequenom iPLEX). Correlation between prostate weight and genotypes from each SNP was studied by analysis of covariance, adjusted on age and tumor stage. A Bonferroni correction was applied, and the SNPs implicated were then incorporated in a multivariable model. Results and limitations: Seven SNPs located in or nearby genes implicated in steroid hormone metabolism were significantly associated with prostate volume: HSD17B2 (rs1119933), ESR2 (rs8006145), SULT2B1 (rs279451), NQO1 (rs2917670), ESR1 (rs1569788), GSTP1 (rs1138272), and CYP19A1 (rs17523880). Significant association was maintained after multivariate analysis for four SNPs, indicating their independent association with prostate volume. The power of the association of each SNP with prostate volume was comparable to the effect of age. The strongest associations were found with variants in ESR1, ESR2, HSD17B2, and CYP19A1 genes, indicating a potential role of the estrogen signaling pathway in genesis of BPH. Conclusions: Our results are in favor of an implication of estrogen biotransformation and signaling pathways in the pathophysiology of BPH.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalWorld Journal of Urology
DOIs
Publication statusAccepted/In press - Jun 8 2016
Externally publishedYes

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Keywords

  • Prostate weight
  • Prostatectomy
  • Single nucleotide polymorphisms
  • Steroid pathway

ASJC Scopus subject areas

  • Urology

Cite this

Cornu, J. N., Audet-Walsh, E., Drouin, S., Bigot, P., Valeri, A., Fournier, G., ... Cancel-Tassin, G. (Accepted/In press). Correlation between prostate volume and single nucleotide polymorphisms implicated in the steroid pathway. World Journal of Urology, 1-6. https://doi.org/10.1007/s00345-016-1869-4