Correlation between PAH airborne concentration and PAH-DNA adducts levels in coke-oven workers

G. Assennato; G. M. Ferris; V. Foà; P. Strickland; M. Poirier; L. Pozzoli; D. Cottica

doi:10.1007/BF00381327

Correlation between PAH airborne concentration and PAH-DNA adducts levels in coke-oven workers

G. Assennato, G. M. Ferris, V. Foà, P. Strickland, M. Poirier, L. Pozzoli, D. Cottica

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

In order to evaluate the correlation between peripheral blood leukocyte DNA adducts as an indicator of exposure to polycyclic aromatic hydrocarbons (PAH) and the airborne contamination of PAH at the work places, a survey of a cohort of coke-oven workers has been carried out. In each workplace, total and specific PAH airborne concentrations were measured. Among the job title groups, the highest proportion of subjects with levels of adducts above the detection limit and the highest mean value were observed in the door-operators. The correlation between median values of environmental benzo(a)pyrene concentration and mean values of adducts concentration support the fact that the maintenance workers group has a higher relative risk (RR) to have detectable level of PAH-adducts, which is estimated to be 1.84 for an increase of 1 μg/m³ of benzo(a)pyrene.

Original language	English (US)
Pages (from-to)	S143-S145
Journal	International Archives of Occupational and Environmental Health
Volume	65
Issue number	1 Supplement
DOIs	https://doi.org/10.1007/BF00381327
State	Published - Jan 1993

Keywords

Coke-oven workers
DNA-adducts
PAHs

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

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10.1007/BF00381327

Cite this

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title = "Correlation between PAH airborne concentration and PAH-DNA adducts levels in coke-oven workers",

abstract = "In order to evaluate the correlation between peripheral blood leukocyte DNA adducts as an indicator of exposure to polycyclic aromatic hydrocarbons (PAH) and the airborne contamination of PAH at the work places, a survey of a cohort of coke-oven workers has been carried out. In each workplace, total and specific PAH airborne concentrations were measured. Among the job title groups, the highest proportion of subjects with levels of adducts above the detection limit and the highest mean value were observed in the door-operators. The correlation between median values of environmental benzo(a)pyrene concentration and mean values of adducts concentration support the fact that the maintenance workers group has a higher relative risk (RR) to have detectable level of PAH-adducts, which is estimated to be 1.84 for an increase of 1 μg/m3 of benzo(a)pyrene.",

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AU - Assennato, G.

AU - Ferris, G. M.

AU - Foà, V.

AU - Strickland, P.

AU - Poirier, M.

AU - Pozzoli, L.

AU - Cottica, D.

PY - 1993/1

Y1 - 1993/1

N2 - In order to evaluate the correlation between peripheral blood leukocyte DNA adducts as an indicator of exposure to polycyclic aromatic hydrocarbons (PAH) and the airborne contamination of PAH at the work places, a survey of a cohort of coke-oven workers has been carried out. In each workplace, total and specific PAH airborne concentrations were measured. Among the job title groups, the highest proportion of subjects with levels of adducts above the detection limit and the highest mean value were observed in the door-operators. The correlation between median values of environmental benzo(a)pyrene concentration and mean values of adducts concentration support the fact that the maintenance workers group has a higher relative risk (RR) to have detectable level of PAH-adducts, which is estimated to be 1.84 for an increase of 1 μg/m3 of benzo(a)pyrene.

AB - In order to evaluate the correlation between peripheral blood leukocyte DNA adducts as an indicator of exposure to polycyclic aromatic hydrocarbons (PAH) and the airborne contamination of PAH at the work places, a survey of a cohort of coke-oven workers has been carried out. In each workplace, total and specific PAH airborne concentrations were measured. Among the job title groups, the highest proportion of subjects with levels of adducts above the detection limit and the highest mean value were observed in the door-operators. The correlation between median values of environmental benzo(a)pyrene concentration and mean values of adducts concentration support the fact that the maintenance workers group has a higher relative risk (RR) to have detectable level of PAH-adducts, which is estimated to be 1.84 for an increase of 1 μg/m3 of benzo(a)pyrene.

KW - Coke-oven workers

KW - DNA-adducts

KW - PAHs

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Correlation between PAH airborne concentration and PAH-DNA adducts levels in coke-oven workers

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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