Correlation between genotype and phenotype in patients with cystic fibrosis

K. H. Gan, H. G.M. Heijerman, W. Bakker, Arie Augarten, Bat Sheva Kerem, Eitan Kerem, Ephraim Gazit, Yaacov Yahav, Ada Hamosh, Mary Corey

Research output: Contribution to journalLetterpeer-review

Abstract

To the Editor: In a recent article Hamosh and Corey of the Cystic Fibrosis Genotype-Phenotype Consortium (Oct. 28 issue)1 reported on correlations between the genotypes and phenotypes of patients with cystic fibrosis. The mean age of the patients with the R117H/ΔF508 genotype was 23.5 years, and the ages of the other groups ranged from 11.0 to 14.6 years. The authors conclude that genotype is predictive of pancreatic status but not of the severity of pulmonary disease. In our adult patient population, however, we found a correlation between the genotype and the severity of pulmonary disease. The rate of decline.

Original languageEnglish (US)
Pages (from-to)865-867
Number of pages3
JournalNew England Journal of Medicine
Volume330
Issue number12
DOIs
StatePublished - Mar 24 1994

ASJC Scopus subject areas

  • Medicine(all)

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