Correlates of sensitization to Blomia tropicalis and Dermatophagoides pteronyssinusin asthma in Barbados

Teri A. Manolio, Kathleen C. Barnes, Raana P. Naidu, Paul N. Levett, Terri H. Beaty, Alexander F. Wilson

Research output: Contribution to journalArticle

Abstract

Background: Sensitivity to the mite Blomia tropicalis is related to asthma in tropical climates, but correlates of sensitivity to B. tropicalis and its relationship to Dermatophagoides pteronyssinus sensitivity have not been widely examined in families with asthma. The main objective of this study was to determine prevalence and correlates of sensitivity to these mites in families with asthma and characteristics of persons sensitized to both. Methods: Antibodies to major antigens (Blo t 5 and Der p 1) of these mites were measured by immunochemiluminescent assay in 481 members of 29 families from Barbados ascertained through two asthmatic siblings. Results: Blo t 5 sensitivity was present in 261 subjects (46%) and was associated with younger age, higher total serum IgE level, and more than a three-fold increased prevalence of asthma (42 vs. 13%). Der p 1 sensitivity was less common (27%) and showed similar associations with age, IgE, and asthma. Of the 261 subjects sensitized to Blo t 5, 116 were also sensitized to Der p 1; they were younger, had higher total and Blo t 5 specific IgE levels, and had more than twice the asthma prevalence as those sensitized to Blo t 5 alone (59 vs. 29%). Der p 1 sensitivity without Blo t 5 sensitivity was uncommon; 90% of those sensitized to Der p 1 were also sensitized to Blo t 5. Geometric mean total IgE levels were lowest in the 207 participants without any mite sensitization (102 U/ml), intermediate in 158 sensitized to either Blo t 5 or Der p 1 (609 U/ml), and highest in 116 sensitized to both (1,869 U/ml). Conclusions: Blo t 5 is the predominant sensitizing mite allergen in these Barbadian families with correlates similar to Der p 1. Concomitant sensitization to Der p 1 appears to identify a more reactive subgroup of individuals at a higher risk of asthma.

Original languageEnglish (US)
Pages (from-to)119-126
Number of pages8
JournalInternational Archives of Allergy and Immunology
Volume131
Issue number2
DOIs
StatePublished - Jun 30 2003

Keywords

  • Asthma
  • Barbados
  • Dust mites
  • IgE

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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