Abstract
Objective To investigate the relative associations of renal function, obesity, and inflammation with serum leptin levels in children with chronic kidney disease (CKD).
Study design This was a cross-sectional analysis of 317 children from the Chronic Kidney Disease in Children study, a large cohort of pediatric patients with stage II-IV CKD. Linear regression modeling was used to evaluate the association of serum leptin level with glomerular filtration rate calculated using the plasma iohexol disappearance curve, demographics, body mass index (BMI), and cardiovascular risk factors, including inflammatory cytokines, insulin resistance, and serum lipid levels.
Results In univariate analyses, elevated serum leptin level was significantly associated with increased BMI, older age, and female sex (P
Conclusion Increased leptin production was associated with female sex, older age, and adiposity in children with mild to moderate CKD. Renal function was not associated with serum leptin level, indicating that decreased clearance does not contribute to elevated leptin levels.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 825-829 |
| Number of pages | 5 |
| Journal | Journal of Pediatrics |
| Volume | 165 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 1 2014 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Medicine(all)
Cite this
Correlates of leptin in children with chronic kidney disease. / Nehus, Edward; Furth, Susan; Warady, Bradley; Mitsnefes, Mark.
In: Journal of Pediatrics, Vol. 165, No. 4, 01.10.2014, p. 825-829.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Correlates of leptin in children with chronic kidney disease
AU - Nehus, Edward
AU - Furth, Susan
AU - Warady, Bradley
AU - Mitsnefes, Mark
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Objective To investigate the relative associations of renal function, obesity, and inflammation with serum leptin levels in children with chronic kidney disease (CKD).Study design This was a cross-sectional analysis of 317 children from the Chronic Kidney Disease in Children study, a large cohort of pediatric patients with stage II-IV CKD. Linear regression modeling was used to evaluate the association of serum leptin level with glomerular filtration rate calculated using the plasma iohexol disappearance curve, demographics, body mass index (BMI), and cardiovascular risk factors, including inflammatory cytokines, insulin resistance, and serum lipid levels.Results In univariate analyses, elevated serum leptin level was significantly associated with increased BMI, older age, and female sex (P Conclusion Increased leptin production was associated with female sex, older age, and adiposity in children with mild to moderate CKD. Renal function was not associated with serum leptin level, indicating that decreased clearance does not contribute to elevated leptin levels.
AB - Objective To investigate the relative associations of renal function, obesity, and inflammation with serum leptin levels in children with chronic kidney disease (CKD).Study design This was a cross-sectional analysis of 317 children from the Chronic Kidney Disease in Children study, a large cohort of pediatric patients with stage II-IV CKD. Linear regression modeling was used to evaluate the association of serum leptin level with glomerular filtration rate calculated using the plasma iohexol disappearance curve, demographics, body mass index (BMI), and cardiovascular risk factors, including inflammatory cytokines, insulin resistance, and serum lipid levels.Results In univariate analyses, elevated serum leptin level was significantly associated with increased BMI, older age, and female sex (P Conclusion Increased leptin production was associated with female sex, older age, and adiposity in children with mild to moderate CKD. Renal function was not associated with serum leptin level, indicating that decreased clearance does not contribute to elevated leptin levels.
UR - http://www.scopus.com/inward/record.url?scp=84908259272&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84908259272&partnerID=8YFLogxK
U2 - 10.1016/j.jpeds.2014.06.030
DO - 10.1016/j.jpeds.2014.06.030
M3 - Article
C2 - 25066063
AN - SCOPUS:84908259272
VL - 165
SP - 825
EP - 829
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 4
ER -