Correlates of leptin in children with chronic kidney disease

Edward Nehus, Susan Furth, Bradley Warady, Mark Mitsnefes

Research output: Contribution to journalArticle

Abstract

Objective To investigate the relative associations of renal function, obesity, and inflammation with serum leptin levels in children with chronic kidney disease (CKD).

Study design This was a cross-sectional analysis of 317 children from the Chronic Kidney Disease in Children study, a large cohort of pediatric patients with stage II-IV CKD. Linear regression modeling was used to evaluate the association of serum leptin level with glomerular filtration rate calculated using the plasma iohexol disappearance curve, demographics, body mass index (BMI), and cardiovascular risk factors, including inflammatory cytokines, insulin resistance, and serum lipid levels.

Results In univariate analyses, elevated serum leptin level was significantly associated with increased BMI, older age, and female sex (P

Conclusion Increased leptin production was associated with female sex, older age, and adiposity in children with mild to moderate CKD. Renal function was not associated with serum leptin level, indicating that decreased clearance does not contribute to elevated leptin levels.

Original languageEnglish (US)
Pages (from-to)825-829
Number of pages5
JournalJournal of Pediatrics
Volume165
Issue number4
DOIs
StatePublished - Oct 1 2014
Externally publishedYes

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Leptin
Chronic Renal Insufficiency
Serum
Body Mass Index
Iohexol
Kidney
Adiposity
Glomerular Filtration Rate
Insulin Resistance
Linear Models
Obesity
Cross-Sectional Studies
Demography
Pediatrics
Cytokines
Inflammation
Lipids

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

Cite this

Correlates of leptin in children with chronic kidney disease. / Nehus, Edward; Furth, Susan; Warady, Bradley; Mitsnefes, Mark.

In: Journal of Pediatrics, Vol. 165, No. 4, 01.10.2014, p. 825-829.

Research output: Contribution to journalArticle

Nehus, E, Furth, S, Warady, B & Mitsnefes, M 2014, 'Correlates of leptin in children with chronic kidney disease', Journal of Pediatrics, vol. 165, no. 4, pp. 825-829. https://doi.org/10.1016/j.jpeds.2014.06.030
Nehus, Edward ; Furth, Susan ; Warady, Bradley ; Mitsnefes, Mark. / Correlates of leptin in children with chronic kidney disease. In: Journal of Pediatrics. 2014 ; Vol. 165, No. 4. pp. 825-829.
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