Correlates of hypertension in patients with AIDS in the era of highly active antiretroviral therapy

Katherine Krauskopf, Mark L.Van Natta, Ronald P. Danis, Sapna Gangaputra, Lori Ackatz, Adrienne Addessi, Alex D. Federman, Andrea D. Branch, Curtis L. Meinert, Douglas A. Jabs

Research output: Contribution to journalArticle

Abstract

Background: It is unclear whether HIV-related factors modify risk of hypertension (HTN). In a cohort of patients with AIDS, the authors determined HTN incidence and prevalence and assessed associated traditional, HIV-specific, and retinal vasculature factors. Methods: Prospective observational cohort included 2390 patients with AIDS (1998-2011). Univariate analysis was used to assess the impact of traditional- and AIDS-related risk factors for HTN prevalence and incidence. Multivariate regression analyses were used to evaluate the adjusted impact of these factors. Results: Hypertension prevalence was 22% (95% confidence interval [CI] 21%-24%) and was associated with traditional HTN risk factors (age, black race, and higher weight) as well as diabetes, hyperlipidemia, time since AIDS diagnosis, and higher CD4 counts. Hypertension incidence was 64.1 per 1000 person-years (95% CI 58.7/1000-69.9/1000). Age, race, weight, and diabetes were associated with incident HTN but HIV-specific factors were not. Conclusions: Hypertension, a prevalent cardiovascular risk factor in patients with AIDS, is associated with traditional and metabolic risk factors.

Original languageEnglish (US)
Pages (from-to)325-333
Number of pages9
JournalJournal of the International Association of Providers of AIDS Care
Volume12
Issue number5
DOIs
StatePublished - Sep 2013

Keywords

  • AIDS
  • HAART
  • HIV
  • cardiovascular risk
  • hypertension

ASJC Scopus subject areas

  • Immunology
  • Dermatology
  • Infectious Diseases

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