Correlates of hypertension in patients with AIDS in the era of highly active antiretroviral therapy

Katherine Krauskopf, Mark L Van Natta, Ronald P. Danis, Sapna Gangaputra, Lori Ackatz, Adrienne Addessi, Alex D. Federman, Andrea D. Branch, Curtis L Meinert, Douglas A. Jabs

Research output: Contribution to journalArticle

Abstract

Background: It is unclear whether HIV-related factors modify risk of hypertension (HTN). In a cohort of patients with AIDS, the authors determined HTN incidence and prevalence and assessed associated traditional, HIV-specific, and retinal vasculature factors. Methods: Prospective observational cohort included 2390 patients with AIDS (1998-2011). Univariate analysis was used to assess the impact of traditional- and AIDS-related risk factors for HTN prevalence and incidence. Multivariate regression analyses were used to evaluate the adjusted impact of these factors. Results: Hypertension prevalence was 22% (95% confidence interval [CI] 21%-24%) and was associated with traditional HTN risk factors (age, black race, and higher weight) as well as diabetes, hyperlipidemia, time since AIDS diagnosis, and higher CD4 counts. Hypertension incidence was 64.1 per 1000 person-years (95% CI 58.7/1000-69.9/1000). Age, race, weight, and diabetes were associated with incident HTN but HIV-specific factors were not. Conclusions: Hypertension, a prevalent cardiovascular risk factor in patients with AIDS, is associated with traditional and metabolic risk factors.

Original languageEnglish (US)
Pages (from-to)325-333
Number of pages9
JournalJournal of the International Association of Providers of AIDS Care
Volume12
Issue number5
DOIs
StatePublished - Sep 2013

Fingerprint

Highly Active Antiretroviral Therapy
Acquired Immunodeficiency Syndrome
Hypertension
HIV
Incidence
Confidence Intervals
Weights and Measures
CD4 Lymphocyte Count
Hyperlipidemias
Multivariate Analysis
Regression Analysis

Keywords

  • AIDS
  • cardiovascular risk
  • HAART
  • HIV
  • hypertension

ASJC Scopus subject areas

  • Immunology
  • Dermatology
  • Infectious Diseases

Cite this

Correlates of hypertension in patients with AIDS in the era of highly active antiretroviral therapy. / Krauskopf, Katherine; Van Natta, Mark L; Danis, Ronald P.; Gangaputra, Sapna; Ackatz, Lori; Addessi, Adrienne; Federman, Alex D.; Branch, Andrea D.; Meinert, Curtis L; Jabs, Douglas A.

In: Journal of the International Association of Providers of AIDS Care, Vol. 12, No. 5, 09.2013, p. 325-333.

Research output: Contribution to journalArticle

Krauskopf, Katherine ; Van Natta, Mark L ; Danis, Ronald P. ; Gangaputra, Sapna ; Ackatz, Lori ; Addessi, Adrienne ; Federman, Alex D. ; Branch, Andrea D. ; Meinert, Curtis L ; Jabs, Douglas A. / Correlates of hypertension in patients with AIDS in the era of highly active antiretroviral therapy. In: Journal of the International Association of Providers of AIDS Care. 2013 ; Vol. 12, No. 5. pp. 325-333.
@article{dafc8b41b5e54bdb85d723db285247a2,
title = "Correlates of hypertension in patients with AIDS in the era of highly active antiretroviral therapy",
abstract = "Background: It is unclear whether HIV-related factors modify risk of hypertension (HTN). In a cohort of patients with AIDS, the authors determined HTN incidence and prevalence and assessed associated traditional, HIV-specific, and retinal vasculature factors. Methods: Prospective observational cohort included 2390 patients with AIDS (1998-2011). Univariate analysis was used to assess the impact of traditional- and AIDS-related risk factors for HTN prevalence and incidence. Multivariate regression analyses were used to evaluate the adjusted impact of these factors. Results: Hypertension prevalence was 22{\%} (95{\%} confidence interval [CI] 21{\%}-24{\%}) and was associated with traditional HTN risk factors (age, black race, and higher weight) as well as diabetes, hyperlipidemia, time since AIDS diagnosis, and higher CD4 counts. Hypertension incidence was 64.1 per 1000 person-years (95{\%} CI 58.7/1000-69.9/1000). Age, race, weight, and diabetes were associated with incident HTN but HIV-specific factors were not. Conclusions: Hypertension, a prevalent cardiovascular risk factor in patients with AIDS, is associated with traditional and metabolic risk factors.",
keywords = "AIDS, cardiovascular risk, HAART, HIV, hypertension",
author = "Katherine Krauskopf and {Van Natta}, {Mark L} and Danis, {Ronald P.} and Sapna Gangaputra and Lori Ackatz and Adrienne Addessi and Federman, {Alex D.} and Branch, {Andrea D.} and Meinert, {Curtis L} and Jabs, {Douglas A.}",
year = "2013",
month = "9",
doi = "10.1177/2325957413491432",
language = "English (US)",
volume = "12",
pages = "325--333",
journal = "Journal of the International Association of Providers of AIDS Care",
issn = "2325-9574",
publisher = "SAGE Publications Inc.",
number = "5",

}

TY - JOUR

T1 - Correlates of hypertension in patients with AIDS in the era of highly active antiretroviral therapy

AU - Krauskopf, Katherine

AU - Van Natta, Mark L

AU - Danis, Ronald P.

AU - Gangaputra, Sapna

AU - Ackatz, Lori

AU - Addessi, Adrienne

AU - Federman, Alex D.

AU - Branch, Andrea D.

AU - Meinert, Curtis L

AU - Jabs, Douglas A.

PY - 2013/9

Y1 - 2013/9

N2 - Background: It is unclear whether HIV-related factors modify risk of hypertension (HTN). In a cohort of patients with AIDS, the authors determined HTN incidence and prevalence and assessed associated traditional, HIV-specific, and retinal vasculature factors. Methods: Prospective observational cohort included 2390 patients with AIDS (1998-2011). Univariate analysis was used to assess the impact of traditional- and AIDS-related risk factors for HTN prevalence and incidence. Multivariate regression analyses were used to evaluate the adjusted impact of these factors. Results: Hypertension prevalence was 22% (95% confidence interval [CI] 21%-24%) and was associated with traditional HTN risk factors (age, black race, and higher weight) as well as diabetes, hyperlipidemia, time since AIDS diagnosis, and higher CD4 counts. Hypertension incidence was 64.1 per 1000 person-years (95% CI 58.7/1000-69.9/1000). Age, race, weight, and diabetes were associated with incident HTN but HIV-specific factors were not. Conclusions: Hypertension, a prevalent cardiovascular risk factor in patients with AIDS, is associated with traditional and metabolic risk factors.

AB - Background: It is unclear whether HIV-related factors modify risk of hypertension (HTN). In a cohort of patients with AIDS, the authors determined HTN incidence and prevalence and assessed associated traditional, HIV-specific, and retinal vasculature factors. Methods: Prospective observational cohort included 2390 patients with AIDS (1998-2011). Univariate analysis was used to assess the impact of traditional- and AIDS-related risk factors for HTN prevalence and incidence. Multivariate regression analyses were used to evaluate the adjusted impact of these factors. Results: Hypertension prevalence was 22% (95% confidence interval [CI] 21%-24%) and was associated with traditional HTN risk factors (age, black race, and higher weight) as well as diabetes, hyperlipidemia, time since AIDS diagnosis, and higher CD4 counts. Hypertension incidence was 64.1 per 1000 person-years (95% CI 58.7/1000-69.9/1000). Age, race, weight, and diabetes were associated with incident HTN but HIV-specific factors were not. Conclusions: Hypertension, a prevalent cardiovascular risk factor in patients with AIDS, is associated with traditional and metabolic risk factors.

KW - AIDS

KW - cardiovascular risk

KW - HAART

KW - HIV

KW - hypertension

UR - http://www.scopus.com/inward/record.url?scp=84884688769&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884688769&partnerID=8YFLogxK

U2 - 10.1177/2325957413491432

DO - 10.1177/2325957413491432

M3 - Article

VL - 12

SP - 325

EP - 333

JO - Journal of the International Association of Providers of AIDS Care

JF - Journal of the International Association of Providers of AIDS Care

SN - 2325-9574

IS - 5

ER -