Correlates of elevated interleukin-6 and C-reactive protein in persons with or at high risk for HCV and HIV infections

Megan L. Salter, Bryan Lau, Shruti H. Mehta, Vivian F. Go, Sean Leng, Gregory D. Kirk

Research output: Contribution to journalArticle

Abstract

BACKGROUND: HIV and hepatitis C virus (HCV) infections may increase interleukin-6 (IL-6) and C-reactive protein (CRP). However, relationships between inflammatory biomarkers, chronic viral infections, clinical factors, and behavioral factors remain poorly understood. METHODS: Using linear regression, we modeled cross-sectional associations between loge IL-6 or loge CRP levels and HCV, HIV, injection drug use, and comorbidity among 1191 injection drug users. RESULTS: Mean age was 47 years, 46.0% reported currently injecting drugs, 59.0% were HCV monoinfected, and 27% were HCV/HIV coinfected. In multivariable models, higher loge IL-6 was associated with HCV monoinfection [β = 0.191, 95% confidence interval (CI): 0.043 to 0.339] and HCV/HIV coinfection (β = 0.394, 95% CI: 0.214 to 0.574). In contrast, HCV monoinfection (β = -0.523, 95% CI: -0.275 to -0.789) and HCV/HIV coinfection (β = -0.554 95% CI: -0.260 to -0.847) were associated with lower CRP. Lower CRP with HCV infection was independent of liver fibrosis severity, synthetic function, or liver injury markers; CRP decreased with higher HCV RNA. Increased injection intensity was associated with higher IL-6 (P = 0.003) and CRP (P < 0.001); increasing comorbidity (P < 0.001) and older age (P = 0.028) were associated with higher IL-6; older age was associated with higher CRP among HCV-uninfected participants (P = 0.021). CONCLUSION: HIV and HCV infections contribute to chronic inflammation; however, reduced CRP possibly occurs through HCV-mediated mechanisms. Findings highlight potentially modifiable contributors to inflammation.

Original languageEnglish (US)
Pages (from-to)488-495
Number of pages8
JournalJournal of acquired immune deficiency syndromes
Volume64
Issue number5
DOIs
StatePublished - Dec 15 2013

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Keywords

  • C-reactive protein
  • HCV
  • HIV
  • comorbidities
  • inflammation
  • injection drug use
  • interleukin-6

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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