Correlates of cervicovaginal human papillomavirus detection in perimenopausal women

Keri Althoff, Proma Paul, Anne Burke, Raphael P Viscidi, Meera Sangaramoorthy, Patti E. Gravitt

Research output: Contribution to journalArticle

Abstract

Objective: The aim of this research was to determine correlates of prevalent cervicovaginal human papillomavirus (HPV) infection in perimenopausal women. Methods: A total of 178 women, ages 40-60, were recruited from four clinics in the metropolitan area of Baltimore, Maryland. A self-collected cervicovaginal specimen and questionnaire were completed following enrollment and consent. HPV was detected by L1 consensus polymerase chain reaction (PCR) and genotyped using a prototype line blot assay. Adjusted prevalence ratios (aPR) and 95% confidence intervals (CIs) from Poisson regression models with robust variance identified correlates of prevalent HPV infection. Results: Prevalence of any HPV genotype at baseline among 172 women with complete data was 20% (6% for high-risk HPV). HPV prevalence was higher among single compared to married women (aPR= 4.3 [95% CI: 2.0, 9.5]), and among women with ≥2 sex partners in the last six months compared to women who reported none (aPR =4.9 [1.7, 13.9]) after adjustment for confounders. Menopausal stage was also associated with HPV detection, with increased prevalence among perimenopausal compared to premenopausal women (aPR 2.3 [1.1, 5.1]), after adjustment for confounders. Age was moderately correlated with menopausal staging (r=0.57). Conclusions: Our observations suggest the independent associations of sexual behavior and hormones on prevalent HPV in perimenopausal women. Age was not a good surrogate for menopausal stage, as it was only moderately correlated with menopausal stage.

Original languageEnglish (US)
Pages (from-to)1341-1346
Number of pages6
JournalJournal of Women's Health
Volume18
Issue number9
DOIs
StatePublished - Sep 1 2009

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Papillomavirus Infections
Confidence Intervals
Baltimore
Sexual Behavior
Consensus
Genotype
Hormones
Polymerase Chain Reaction
Research
Surveys and Questionnaires

ASJC Scopus subject areas

  • Medicine(all)

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Correlates of cervicovaginal human papillomavirus detection in perimenopausal women. / Althoff, Keri; Paul, Proma; Burke, Anne; Viscidi, Raphael P; Sangaramoorthy, Meera; Gravitt, Patti E.

In: Journal of Women's Health, Vol. 18, No. 9, 01.09.2009, p. 1341-1346.

Research output: Contribution to journalArticle

Althoff, Keri ; Paul, Proma ; Burke, Anne ; Viscidi, Raphael P ; Sangaramoorthy, Meera ; Gravitt, Patti E. / Correlates of cervicovaginal human papillomavirus detection in perimenopausal women. In: Journal of Women's Health. 2009 ; Vol. 18, No. 9. pp. 1341-1346.
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