Correlates of aortic stiffness in elderly individuals

A subgroup of the cardiovascular health study

Rachel H. Mackey, Kim Sutton-Tyrrell, Peter V. Vaitkevicius, Pamela A. Sakkinen, Mary F. Lyles, Harold A. Spurgeon, Edward Lakatta, Lewis H. Kuller

Research output: Contribution to journalArticle

Abstract

Background: Arterial stiffness has been associated with aging, hypertension, and diabetes; however, little data has been published examining risk factors associated with arterial stiffness in elderly individuals. Methods: Longitudinal associations were made between aortic stiffness and risk factors measured approximately 4 years earlier. Aortic pulse wave velocity (PWV), an established index of arterial stiffness, was measured in 356 participants (53.4% women, 25.3% African American), aged 70 to 96 years, from the Pittsburgh site of the Cardiovascular Health Study during 1996 to 1998. Results: Mean aortic pulse wave velocity (850 cra/sec, range 365 to 1863) did not differ by ethnicity or sex. Increased aortic stiffness was positively associated with higher systolic blood pressure (SBP), age, fasting and 2-h postload glucose, fasting and 2-h insulin, triglycerides, waist circumference, body mass index, truncal fat, decreased physical activity, heart rate, and common carotid artery wall thickness (P < .05). After controlling for age and SBP, the strongest predictors of aortic stiffness in men were heart rate (P = .001) and 2-h glucose (P = .063). In women, PWV was positively associated with heart rate (P = .018), use of antihypertensive medication (P = .035), waist circumference (P = .030), and triglycerides (P = .081), and was negatively associated with physical activity (P = .111). Results were similar when the analysis was repeated in nondiabetic individuals and in those free of clinical or subclinical cardiovascular disease in 1992 to 1993. Conclusions: In these elderly participants, aortic stiffness was positively associated with risk factors associated with the insulin resistance syndrome, increased common carotid intima-media thickness, heart rate, and decreased physical activity measured several years earlier.

Original languageEnglish (US)
Pages (from-to)16-23
Number of pages8
JournalAmerican Journal of Hypertension
Volume15
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

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Vascular Stiffness
Health
Pulse Wave Analysis
Heart Rate
Waist Circumference
Exercise
Blood Pressure
Fasting
Triglycerides
Hypertension
Glucose
Carotid Intima-Media Thickness
Common Carotid Artery
African Americans
Antihypertensive Agents
Insulin Resistance
Body Mass Index
Cardiovascular Diseases
Fats
Insulin

Keywords

  • Aging
  • Arterial stiffness
  • Heart rate
  • Insulin resistance
  • Pulse wave velocity

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Mackey, R. H., Sutton-Tyrrell, K., Vaitkevicius, P. V., Sakkinen, P. A., Lyles, M. F., Spurgeon, H. A., ... Kuller, L. H. (2002). Correlates of aortic stiffness in elderly individuals: A subgroup of the cardiovascular health study. American Journal of Hypertension, 15(1), 16-23. https://doi.org/10.1016/S0895-7061(01)02228-2

Correlates of aortic stiffness in elderly individuals : A subgroup of the cardiovascular health study. / Mackey, Rachel H.; Sutton-Tyrrell, Kim; Vaitkevicius, Peter V.; Sakkinen, Pamela A.; Lyles, Mary F.; Spurgeon, Harold A.; Lakatta, Edward; Kuller, Lewis H.

In: American Journal of Hypertension, Vol. 15, No. 1, 2002, p. 16-23.

Research output: Contribution to journalArticle

Mackey, RH, Sutton-Tyrrell, K, Vaitkevicius, PV, Sakkinen, PA, Lyles, MF, Spurgeon, HA, Lakatta, E & Kuller, LH 2002, 'Correlates of aortic stiffness in elderly individuals: A subgroup of the cardiovascular health study', American Journal of Hypertension, vol. 15, no. 1, pp. 16-23. https://doi.org/10.1016/S0895-7061(01)02228-2
Mackey, Rachel H. ; Sutton-Tyrrell, Kim ; Vaitkevicius, Peter V. ; Sakkinen, Pamela A. ; Lyles, Mary F. ; Spurgeon, Harold A. ; Lakatta, Edward ; Kuller, Lewis H. / Correlates of aortic stiffness in elderly individuals : A subgroup of the cardiovascular health study. In: American Journal of Hypertension. 2002 ; Vol. 15, No. 1. pp. 16-23.
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T2 - A subgroup of the cardiovascular health study

AU - Mackey, Rachel H.

AU - Sutton-Tyrrell, Kim

AU - Vaitkevicius, Peter V.

AU - Sakkinen, Pamela A.

AU - Lyles, Mary F.

AU - Spurgeon, Harold A.

AU - Lakatta, Edward

AU - Kuller, Lewis H.

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AB - Background: Arterial stiffness has been associated with aging, hypertension, and diabetes; however, little data has been published examining risk factors associated with arterial stiffness in elderly individuals. Methods: Longitudinal associations were made between aortic stiffness and risk factors measured approximately 4 years earlier. Aortic pulse wave velocity (PWV), an established index of arterial stiffness, was measured in 356 participants (53.4% women, 25.3% African American), aged 70 to 96 years, from the Pittsburgh site of the Cardiovascular Health Study during 1996 to 1998. Results: Mean aortic pulse wave velocity (850 cra/sec, range 365 to 1863) did not differ by ethnicity or sex. Increased aortic stiffness was positively associated with higher systolic blood pressure (SBP), age, fasting and 2-h postload glucose, fasting and 2-h insulin, triglycerides, waist circumference, body mass index, truncal fat, decreased physical activity, heart rate, and common carotid artery wall thickness (P < .05). After controlling for age and SBP, the strongest predictors of aortic stiffness in men were heart rate (P = .001) and 2-h glucose (P = .063). In women, PWV was positively associated with heart rate (P = .018), use of antihypertensive medication (P = .035), waist circumference (P = .030), and triglycerides (P = .081), and was negatively associated with physical activity (P = .111). Results were similar when the analysis was repeated in nondiabetic individuals and in those free of clinical or subclinical cardiovascular disease in 1992 to 1993. Conclusions: In these elderly participants, aortic stiffness was positively associated with risk factors associated with the insulin resistance syndrome, increased common carotid intima-media thickness, heart rate, and decreased physical activity measured several years earlier.

KW - Aging

KW - Arterial stiffness

KW - Heart rate

KW - Insulin resistance

KW - Pulse wave velocity

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