Correction

The complex genetics of gait speed: Genome-wide metaanalysis approach [Aging, (Albany NY), 9, 1, (2017), (209-246)]doi 10.18632/aging.101151

Dan Ben-Avraham, David Karasik, Joe Verghese, Kathryn L. Lunetta, Jennifer A. Smith, John D. Eicher, Rotem Vered, Joris Deelen, Alice M. Arnold, Aron S. Buchman, Toshiko Tanaka, Jessica D. Faul, Maria Nethander, Myriam Fornage, Hieab H. Adams, Amy M. Matteini, Michele L. Callisaya, Albert V. Smith, Lei Yu, Philip L. De Jager & 50 others Denis A. Evans, Vilmundur Gudnason, Albert Hofman, Alison Pattie, Janie Corley, Lenore J. Launer, Davis S. Knopman, Neeta Parimi, Stephen T. Turner, Stefania Bandinelli, Marian Beekman, Danielle Gutman, Lital Sharvit, Simon P. Mooijaart, David C. Liewald, Jeanine J. Houwing-Duistermaat, Claes Ohlsson, Matthijs Moed, Vincent J. Verlinden, Dan Mellström, Jos N. van der Geest, Magnus Karlsson, Dena Hernandez, Rebekah McWhirter, Yongmei Liu, Russell Thomson, Gregory J. Tranah, Andre G. Uitterlinden, David R. Weir, Wei Zhao, John M. Starr, Andrew D. Johnson, M. Arfan Ikram, David A. Bennett, Steven R. Cummings, Ian J. Deary, Tamara B. Harris, Sharon L.R. Kardia, Thomas H. Mosley, Velandai K. Srikanth, Beverly G. Windham, Ann B. Newman, Jeremy D Walston, Gail Davies, Daniel S. Evans, Eline P. Slagboom, Luigi Ferrucci, Douglas P. Kiel, Joanne M. Murabito, Gil Atzmon

Research output: Contribution to journalComment/debate

Abstract

Applying HaploReg v4.1 analysis to the 536 variants resulted in 9 categories (Supplementary Table 8): miscRNA (1 variant); snoRNA (2 variants); microRNA (4 variants); snRNA (9 variants); pseudogenes (14 variants); sequencing in progress (43 variants); LINC RNA (86 variants); and 372 variants within protein coding genes. In addition, some variants annotate to the same gene resulting in a total of 139 genes (protein-coding or non-coding). Of those genes, 6 are exceptionally long, containing over a million base-pairs, the longest of which is PTPRT coded by 1117219bp. The shortest genes are the ones coding for micro (MIR3143) or small nuclear (U7) RNAs at 63bp each. There is only partial information regarding the chromatin state of each variant. However, from the information gathered in the analysis we observed 14 transcription start sites and 245 enhancers (Supplementary Table 8).

Original languageEnglish (US)
Pages (from-to)1844-1846
Number of pages3
JournalAging
Volume9
Issue number7
DOIs
StatePublished - Jul 1 2017

Fingerprint

Genome
Small Nucleolar RNA
Long Noncoding RNA
Genes
Small Nuclear RNA
Pseudogenes
Transcription Initiation Site
MicroRNAs
Base Pairing
Chromatin
Proteins
Walking Speed
U7 small nuclear RNA

ASJC Scopus subject areas

  • Aging
  • Cell Biology

Cite this

Ben-Avraham, D., Karasik, D., Verghese, J., Lunetta, K. L., Smith, J. A., Eicher, J. D., ... Atzmon, G. (2017). Correction: The complex genetics of gait speed: Genome-wide metaanalysis approach [Aging, (Albany NY), 9, 1, (2017), (209-246)]doi 10.18632/aging.101151. Aging, 9(7), 1844-1846. https://doi.org/10.18632/aging.101260

Correction : The complex genetics of gait speed: Genome-wide metaanalysis approach [Aging, (Albany NY), 9, 1, (2017), (209-246)]doi 10.18632/aging.101151. / Ben-Avraham, Dan; Karasik, David; Verghese, Joe; Lunetta, Kathryn L.; Smith, Jennifer A.; Eicher, John D.; Vered, Rotem; Deelen, Joris; Arnold, Alice M.; Buchman, Aron S.; Tanaka, Toshiko; Faul, Jessica D.; Nethander, Maria; Fornage, Myriam; Adams, Hieab H.; Matteini, Amy M.; Callisaya, Michele L.; Smith, Albert V.; Yu, Lei; De Jager, Philip L.; Evans, Denis A.; Gudnason, Vilmundur; Hofman, Albert; Pattie, Alison; Corley, Janie; Launer, Lenore J.; Knopman, Davis S.; Parimi, Neeta; Turner, Stephen T.; Bandinelli, Stefania; Beekman, Marian; Gutman, Danielle; Sharvit, Lital; Mooijaart, Simon P.; Liewald, David C.; Houwing-Duistermaat, Jeanine J.; Ohlsson, Claes; Moed, Matthijs; Verlinden, Vincent J.; Mellström, Dan; van der Geest, Jos N.; Karlsson, Magnus; Hernandez, Dena; McWhirter, Rebekah; Liu, Yongmei; Thomson, Russell; Tranah, Gregory J.; Uitterlinden, Andre G.; Weir, David R.; Zhao, Wei; Starr, John M.; Johnson, Andrew D.; Arfan Ikram, M.; Bennett, David A.; Cummings, Steven R.; Deary, Ian J.; Harris, Tamara B.; Kardia, Sharon L.R.; Mosley, Thomas H.; Srikanth, Velandai K.; Windham, Beverly G.; Newman, Ann B.; Walston, Jeremy D; Davies, Gail; Evans, Daniel S.; Slagboom, Eline P.; Ferrucci, Luigi; Kiel, Douglas P.; Murabito, Joanne M.; Atzmon, Gil.

In: Aging, Vol. 9, No. 7, 01.07.2017, p. 1844-1846.

Research output: Contribution to journalComment/debate

Ben-Avraham, D, Karasik, D, Verghese, J, Lunetta, KL, Smith, JA, Eicher, JD, Vered, R, Deelen, J, Arnold, AM, Buchman, AS, Tanaka, T, Faul, JD, Nethander, M, Fornage, M, Adams, HH, Matteini, AM, Callisaya, ML, Smith, AV, Yu, L, De Jager, PL, Evans, DA, Gudnason, V, Hofman, A, Pattie, A, Corley, J, Launer, LJ, Knopman, DS, Parimi, N, Turner, ST, Bandinelli, S, Beekman, M, Gutman, D, Sharvit, L, Mooijaart, SP, Liewald, DC, Houwing-Duistermaat, JJ, Ohlsson, C, Moed, M, Verlinden, VJ, Mellström, D, van der Geest, JN, Karlsson, M, Hernandez, D, McWhirter, R, Liu, Y, Thomson, R, Tranah, GJ, Uitterlinden, AG, Weir, DR, Zhao, W, Starr, JM, Johnson, AD, Arfan Ikram, M, Bennett, DA, Cummings, SR, Deary, IJ, Harris, TB, Kardia, SLR, Mosley, TH, Srikanth, VK, Windham, BG, Newman, AB, Walston, JD, Davies, G, Evans, DS, Slagboom, EP, Ferrucci, L, Kiel, DP, Murabito, JM & Atzmon, G 2017, 'Correction: The complex genetics of gait speed: Genome-wide metaanalysis approach [Aging, (Albany NY), 9, 1, (2017), (209-246)]doi 10.18632/aging.101151', Aging, vol. 9, no. 7, pp. 1844-1846. https://doi.org/10.18632/aging.101260
Ben-Avraham, Dan ; Karasik, David ; Verghese, Joe ; Lunetta, Kathryn L. ; Smith, Jennifer A. ; Eicher, John D. ; Vered, Rotem ; Deelen, Joris ; Arnold, Alice M. ; Buchman, Aron S. ; Tanaka, Toshiko ; Faul, Jessica D. ; Nethander, Maria ; Fornage, Myriam ; Adams, Hieab H. ; Matteini, Amy M. ; Callisaya, Michele L. ; Smith, Albert V. ; Yu, Lei ; De Jager, Philip L. ; Evans, Denis A. ; Gudnason, Vilmundur ; Hofman, Albert ; Pattie, Alison ; Corley, Janie ; Launer, Lenore J. ; Knopman, Davis S. ; Parimi, Neeta ; Turner, Stephen T. ; Bandinelli, Stefania ; Beekman, Marian ; Gutman, Danielle ; Sharvit, Lital ; Mooijaart, Simon P. ; Liewald, David C. ; Houwing-Duistermaat, Jeanine J. ; Ohlsson, Claes ; Moed, Matthijs ; Verlinden, Vincent J. ; Mellström, Dan ; van der Geest, Jos N. ; Karlsson, Magnus ; Hernandez, Dena ; McWhirter, Rebekah ; Liu, Yongmei ; Thomson, Russell ; Tranah, Gregory J. ; Uitterlinden, Andre G. ; Weir, David R. ; Zhao, Wei ; Starr, John M. ; Johnson, Andrew D. ; Arfan Ikram, M. ; Bennett, David A. ; Cummings, Steven R. ; Deary, Ian J. ; Harris, Tamara B. ; Kardia, Sharon L.R. ; Mosley, Thomas H. ; Srikanth, Velandai K. ; Windham, Beverly G. ; Newman, Ann B. ; Walston, Jeremy D ; Davies, Gail ; Evans, Daniel S. ; Slagboom, Eline P. ; Ferrucci, Luigi ; Kiel, Douglas P. ; Murabito, Joanne M. ; Atzmon, Gil. / Correction : The complex genetics of gait speed: Genome-wide metaanalysis approach [Aging, (Albany NY), 9, 1, (2017), (209-246)]doi 10.18632/aging.101151. In: Aging. 2017 ; Vol. 9, No. 7. pp. 1844-1846.
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title = "Correction: The complex genetics of gait speed: Genome-wide metaanalysis approach [Aging, (Albany NY), 9, 1, (2017), (209-246)]doi 10.18632/aging.101151",
abstract = "Applying HaploReg v4.1 analysis to the 536 variants resulted in 9 categories (Supplementary Table 8): miscRNA (1 variant); snoRNA (2 variants); microRNA (4 variants); snRNA (9 variants); pseudogenes (14 variants); sequencing in progress (43 variants); LINC RNA (86 variants); and 372 variants within protein coding genes. In addition, some variants annotate to the same gene resulting in a total of 139 genes (protein-coding or non-coding). Of those genes, 6 are exceptionally long, containing over a million base-pairs, the longest of which is PTPRT coded by 1117219bp. The shortest genes are the ones coding for micro (MIR3143) or small nuclear (U7) RNAs at 63bp each. There is only partial information regarding the chromatin state of each variant. However, from the information gathered in the analysis we observed 14 transcription start sites and 245 enhancers (Supplementary Table 8).",
author = "Dan Ben-Avraham and David Karasik and Joe Verghese and Lunetta, {Kathryn L.} and Smith, {Jennifer A.} and Eicher, {John D.} and Rotem Vered and Joris Deelen and Arnold, {Alice M.} and Buchman, {Aron S.} and Toshiko Tanaka and Faul, {Jessica D.} and Maria Nethander and Myriam Fornage and Adams, {Hieab H.} and Matteini, {Amy M.} and Callisaya, {Michele L.} and Smith, {Albert V.} and Lei Yu and {De Jager}, {Philip L.} and Evans, {Denis A.} and Vilmundur Gudnason and Albert Hofman and Alison Pattie and Janie Corley and Launer, {Lenore J.} and Knopman, {Davis S.} and Neeta Parimi and Turner, {Stephen T.} and Stefania Bandinelli and Marian Beekman and Danielle Gutman and Lital Sharvit and Mooijaart, {Simon P.} and Liewald, {David C.} and Houwing-Duistermaat, {Jeanine J.} and Claes Ohlsson and Matthijs Moed and Verlinden, {Vincent J.} and Dan Mellstr{\"o}m and {van der Geest}, {Jos N.} and Magnus Karlsson and Dena Hernandez and Rebekah McWhirter and Yongmei Liu and Russell Thomson and Tranah, {Gregory J.} and Uitterlinden, {Andre G.} and Weir, {David R.} and Wei Zhao and Starr, {John M.} and Johnson, {Andrew D.} and {Arfan Ikram}, M. and Bennett, {David A.} and Cummings, {Steven R.} and Deary, {Ian J.} and Harris, {Tamara B.} and Kardia, {Sharon L.R.} and Mosley, {Thomas H.} and Srikanth, {Velandai K.} and Windham, {Beverly G.} and Newman, {Ann B.} and Walston, {Jeremy D} and Gail Davies and Evans, {Daniel S.} and Slagboom, {Eline P.} and Luigi Ferrucci and Kiel, {Douglas P.} and Murabito, {Joanne M.} and Gil Atzmon",
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TY - JOUR

T1 - Correction

T2 - The complex genetics of gait speed: Genome-wide metaanalysis approach [Aging, (Albany NY), 9, 1, (2017), (209-246)]doi 10.18632/aging.101151

AU - Ben-Avraham, Dan

AU - Karasik, David

AU - Verghese, Joe

AU - Lunetta, Kathryn L.

AU - Smith, Jennifer A.

AU - Eicher, John D.

AU - Vered, Rotem

AU - Deelen, Joris

AU - Arnold, Alice M.

AU - Buchman, Aron S.

AU - Tanaka, Toshiko

AU - Faul, Jessica D.

AU - Nethander, Maria

AU - Fornage, Myriam

AU - Adams, Hieab H.

AU - Matteini, Amy M.

AU - Callisaya, Michele L.

AU - Smith, Albert V.

AU - Yu, Lei

AU - De Jager, Philip L.

AU - Evans, Denis A.

AU - Gudnason, Vilmundur

AU - Hofman, Albert

AU - Pattie, Alison

AU - Corley, Janie

AU - Launer, Lenore J.

AU - Knopman, Davis S.

AU - Parimi, Neeta

AU - Turner, Stephen T.

AU - Bandinelli, Stefania

AU - Beekman, Marian

AU - Gutman, Danielle

AU - Sharvit, Lital

AU - Mooijaart, Simon P.

AU - Liewald, David C.

AU - Houwing-Duistermaat, Jeanine J.

AU - Ohlsson, Claes

AU - Moed, Matthijs

AU - Verlinden, Vincent J.

AU - Mellström, Dan

AU - van der Geest, Jos N.

AU - Karlsson, Magnus

AU - Hernandez, Dena

AU - McWhirter, Rebekah

AU - Liu, Yongmei

AU - Thomson, Russell

AU - Tranah, Gregory J.

AU - Uitterlinden, Andre G.

AU - Weir, David R.

AU - Zhao, Wei

AU - Starr, John M.

AU - Johnson, Andrew D.

AU - Arfan Ikram, M.

AU - Bennett, David A.

AU - Cummings, Steven R.

AU - Deary, Ian J.

AU - Harris, Tamara B.

AU - Kardia, Sharon L.R.

AU - Mosley, Thomas H.

AU - Srikanth, Velandai K.

AU - Windham, Beverly G.

AU - Newman, Ann B.

AU - Walston, Jeremy D

AU - Davies, Gail

AU - Evans, Daniel S.

AU - Slagboom, Eline P.

AU - Ferrucci, Luigi

AU - Kiel, Douglas P.

AU - Murabito, Joanne M.

AU - Atzmon, Gil

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Applying HaploReg v4.1 analysis to the 536 variants resulted in 9 categories (Supplementary Table 8): miscRNA (1 variant); snoRNA (2 variants); microRNA (4 variants); snRNA (9 variants); pseudogenes (14 variants); sequencing in progress (43 variants); LINC RNA (86 variants); and 372 variants within protein coding genes. In addition, some variants annotate to the same gene resulting in a total of 139 genes (protein-coding or non-coding). Of those genes, 6 are exceptionally long, containing over a million base-pairs, the longest of which is PTPRT coded by 1117219bp. The shortest genes are the ones coding for micro (MIR3143) or small nuclear (U7) RNAs at 63bp each. There is only partial information regarding the chromatin state of each variant. However, from the information gathered in the analysis we observed 14 transcription start sites and 245 enhancers (Supplementary Table 8).

AB - Applying HaploReg v4.1 analysis to the 536 variants resulted in 9 categories (Supplementary Table 8): miscRNA (1 variant); snoRNA (2 variants); microRNA (4 variants); snRNA (9 variants); pseudogenes (14 variants); sequencing in progress (43 variants); LINC RNA (86 variants); and 372 variants within protein coding genes. In addition, some variants annotate to the same gene resulting in a total of 139 genes (protein-coding or non-coding). Of those genes, 6 are exceptionally long, containing over a million base-pairs, the longest of which is PTPRT coded by 1117219bp. The shortest genes are the ones coding for micro (MIR3143) or small nuclear (U7) RNAs at 63bp each. There is only partial information regarding the chromatin state of each variant. However, from the information gathered in the analysis we observed 14 transcription start sites and 245 enhancers (Supplementary Table 8).

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U2 - 10.18632/aging.101260

DO - 10.18632/aging.101260

M3 - Comment/debate

VL - 9

SP - 1844

EP - 1846

JO - Aging

JF - Aging

SN - 1945-4589

IS - 7

ER -