After publication of this article , it came to light that there were errors in the reported glomerular filtration rate (GFR) estimates. The two-fold purpose of this paper  was to 1) compare accuracy and bias of widely used glomerular filtration rate (GFR) estimating equations to a gold-standard GFR measure (iohexol disappearance from plasma) in HIV-positive and HIV-negative volunteers, and 2) to assess factors associated with bias and accuracy of the creatinine-based and cystatin C-based equations. Recently, our co-investigators, who performed the laboratory analyses and calculations for the iohexol GFR, identified a drift that occurred in their measurement of iohexol (prior to this study) that led to an across-the-board underestimation of iohexol concentrations from blood samples, which produced a systematic overestimation of GFR by approximately 10%. This measurement error in this laboratory was described in a publication in 2017. We subsequently repeated the analyses in the PLOS ONE paper using recalibrated (corrected) iohexol GFR values provided here in an updated version of Table 1. (Table Presented).
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)