Correcting for multivariate measurement error by regression calibration in meta-analyses of epidemiological studies

Angela Mary Wood, S. G. Thompson, J. B. Kostis, A. C. Wilson, K. Wu, M. Benderly, U. Goldbourt, J. Willeit, S. Kiechl, J. W.G. Yarnell, P. M. Sweetman, P. C. Elwood, M. Cushman, R. P. Tracy, A. Tybjærg-Hansen, F. Haverkate, A. J. Lee, F. B. Smith, V. Salomaa, K. HaraldV. Rasi, P. Jousilahti, J. Pekkanen, R. D'Agostino, P. W.F. Wilson, G. Tofler, D. Levy, R. Marchioli, F. Valagussa, A. Rosengren, G. Lappas, H. Eriksson, P. Cremer, D. Nagel, J. D. Curb, B. Rodriguez, K. Yano, J. T. Salonen, K. Nyyssönen, T. P. Tuomainen, B. Hedblad, G. Engström, G. Berglund, H. Loewel, H. W. Hense, T. W. Mead, J. A. Cooper, B. De Stavola, C. Knottenbelt, G. J. Miller, J. A. Cooper, K. A. Bauer, R. D. Rosenberg, S. Sato, A. Kitamura, Y. Naito, H. Iso, K. Harald, V. Rasi, E. Vahtera, P. Jousilahti, T. Palosuo, P. Ducimetriere, P. Amouyel, D. Arveiler, A. E. Evans, J. Ferrieres, I. Juhan-Vague, A. Bingham, H. Schulte, G. Assmann, B. Cantin, B. Lamarche, J. P. Després, H. Tunstall-Pedoe, G. D.O. Lowe, M. Woodward, Y. Ben-Shlomo, G. Davey Smith, V. Palmieri, J. L. Yeh, T. W. Meade, P. Brennan, C. Knottenbelt, P. Ridker, F. Rodeghiero, A. Tosetto, J. Shepherd, G. D.O. Lowe, I. Ford, M. Robertson, E. Brunner, M. Shipley, E. J.M. Feskens, D. Kromhout, E. Di Angelantonio, S. Kaptoge, S. Lewington, G. D.O. Lowe

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Within-person variability in measured values of multiple risk factors can bias their associations with disease. The multivariate regression calibration (RC) approach can correct for such measurement error and has been applied to studies in which true values or independent repeat measurements of the risk factors are observed on a subsample. We extend the multivariate RC techniques to a meta-analysis framework where multiple studies provide independent repeat measurements and information on disease outcome. We consider the cases where some or all studies have repeat measurements, and compare study-specific, averaged and empirical Bayes estimates of RC parameters. Additionally, we allow for binary covariates (e.g. smoking status) and for uncertainty and time trends in the measurement error corrections. Our methods are illustrated using a subset of individual participant data from prospective long-term studies in the Fibrinogen Studies Collaboration to assess the relationship between usual levels of plasma fibrinogen and the risk of coronary heart disease, allowing for measurement error in plasma fibrinogen and several confounders.

Original languageEnglish (US)
Pages (from-to)1067-1092
Number of pages26
JournalStatistics in Medicine
Issue number7
StatePublished - Mar 30 2009
Externally publishedYes


  • Individual participant data
  • Measurement error
  • Meta-analysis
  • Regression calibration
  • Within-person variation

ASJC Scopus subject areas

  • Epidemiology
  • Statistics and Probability


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