Corpus callosum segment circumference is associated with response control in children with attention-deficit hyperactivity disorder (ADHD)

Research output: Contribution to journalArticle

Abstract

Response control is impaired in attention-deficit hyperactivity disorder (ADHD). Given the corpus callosums role in response control, we compared callosal morphology in 64 children with ADHD and 64 typically developing children, aged 7 to 13 years, and investigated the relationships between callosal morphology and response control. Area and circumference of 5 callosal segments (genu, rostral body, midbody, isthmus, and splenium) were normalized for cerebral volume and examined for correlation with mean reaction time, intrasubject variability, and/or commission error rate from a go/no-go task. There were no between-group differences in segment areas or circumferences. Reaction time correlated with midbody circumference for boys with ADHD and isthmus circumference for girls with ADHD. For the entire cohort, rostral body circumference correlated with intrasubject variability. Impaired response control in ADHD is associated with anomalies in frontal interhemispheric connections. Future studies examining callosal shape will illuminate the anatomic basis of correlations between callosal segment circumference and response control.

Original languageEnglish (US)
Pages (from-to)453-462
Number of pages10
JournalJournal of Child Neurology
Volume25
Issue number4
DOIs
StatePublished - Apr 2010

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Corpus Callosum
Attention Deficit Disorder with Hyperactivity

Keywords

  • ADHD
  • Circumference
  • Corpus callosum
  • Reaction time
  • Response control
  • White matter

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

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title = "Corpus callosum segment circumference is associated with response control in children with attention-deficit hyperactivity disorder (ADHD)",
abstract = "Response control is impaired in attention-deficit hyperactivity disorder (ADHD). Given the corpus callosums role in response control, we compared callosal morphology in 64 children with ADHD and 64 typically developing children, aged 7 to 13 years, and investigated the relationships between callosal morphology and response control. Area and circumference of 5 callosal segments (genu, rostral body, midbody, isthmus, and splenium) were normalized for cerebral volume and examined for correlation with mean reaction time, intrasubject variability, and/or commission error rate from a go/no-go task. There were no between-group differences in segment areas or circumferences. Reaction time correlated with midbody circumference for boys with ADHD and isthmus circumference for girls with ADHD. For the entire cohort, rostral body circumference correlated with intrasubject variability. Impaired response control in ADHD is associated with anomalies in frontal interhemispheric connections. Future studies examining callosal shape will illuminate the anatomic basis of correlations between callosal segment circumference and response control.",
keywords = "ADHD, Circumference, Corpus callosum, Reaction time, Response control, White matter",
author = "McNally, {Melanie A.} and Deana Crocetti and Mahone, {Ernest M} and Denckla, {Martha Bridge} and Suskauer, {Stacy Jennifer M} and Mostofsky, {Stewart H}",
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AU - Suskauer, Stacy Jennifer M

AU - Mostofsky, Stewart H

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N2 - Response control is impaired in attention-deficit hyperactivity disorder (ADHD). Given the corpus callosums role in response control, we compared callosal morphology in 64 children with ADHD and 64 typically developing children, aged 7 to 13 years, and investigated the relationships between callosal morphology and response control. Area and circumference of 5 callosal segments (genu, rostral body, midbody, isthmus, and splenium) were normalized for cerebral volume and examined for correlation with mean reaction time, intrasubject variability, and/or commission error rate from a go/no-go task. There were no between-group differences in segment areas or circumferences. Reaction time correlated with midbody circumference for boys with ADHD and isthmus circumference for girls with ADHD. For the entire cohort, rostral body circumference correlated with intrasubject variability. Impaired response control in ADHD is associated with anomalies in frontal interhemispheric connections. Future studies examining callosal shape will illuminate the anatomic basis of correlations between callosal segment circumference and response control.

AB - Response control is impaired in attention-deficit hyperactivity disorder (ADHD). Given the corpus callosums role in response control, we compared callosal morphology in 64 children with ADHD and 64 typically developing children, aged 7 to 13 years, and investigated the relationships between callosal morphology and response control. Area and circumference of 5 callosal segments (genu, rostral body, midbody, isthmus, and splenium) were normalized for cerebral volume and examined for correlation with mean reaction time, intrasubject variability, and/or commission error rate from a go/no-go task. There were no between-group differences in segment areas or circumferences. Reaction time correlated with midbody circumference for boys with ADHD and isthmus circumference for girls with ADHD. For the entire cohort, rostral body circumference correlated with intrasubject variability. Impaired response control in ADHD is associated with anomalies in frontal interhemispheric connections. Future studies examining callosal shape will illuminate the anatomic basis of correlations between callosal segment circumference and response control.

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