Abstract
The aim of this study was to investigate the morphology of the corpus callosum (CC) in Tourette syndrome (TS) and attention deficit hyperactivity disorder (ADHD) to determine whether these conditions affect distinct regional differences. Seventy-seven children and adolescents, aged 6 to 16 years, comprised the four research groups-16 patients with TS, 21 patients with TS plus ADHD, 13 patients with ADHD, and 27 unaffected control subjects. A semiautomated, computer-assisted procedure was used to measure the total area, five subregions, centerline length, perimeter, and bending angle of the CC. MRI data were analyzed using several statistical methods, primarily two- tailed analysis of variance to test the effects of TS and ADHD status, while controlling for the influence of age, gender, and total intracranial area (an estimate of brain size). TS was associated with significant increases in the area of four of five subdivisions, the total area, and the perimeter of the CC. ADHD was associated with a significant decrease in the area of the restral body. There were no interactions between TS and ADHD factors. These findings suggest that the area of the CC is larger in children with TS, and that this difference is independent of age, handedness, intracranial area, and the diagnosis of ADHD. Our findings support hypotheses that the neurobiologic mechanisms in TS and ADHD involve-frontal/subcortical circuits.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 477-482 |
| Number of pages | 6 |
| Journal | Neurology |
| Volume | 47 |
| Issue number | 2 |
| State | Published - Aug 1996 |
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ASJC Scopus subject areas
- Neuroscience(all)
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Corpus callosum morphology in children with Tourette syndrome and attention deficit hyperactivity disorder. / Baumgardner, T. L.; Singer, Harvey; Denckla, Martha Bridge; Rubin, M. A.; Abrams, M. T.; Colli, M. J.; Reiss, A. L.
In: Neurology, Vol. 47, No. 2, 08.1996, p. 477-482.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Corpus callosum morphology in children with Tourette syndrome and attention deficit hyperactivity disorder
AU - Baumgardner, T. L.
AU - Singer, Harvey
AU - Denckla, Martha Bridge
AU - Rubin, M. A.
AU - Abrams, M. T.
AU - Colli, M. J.
AU - Reiss, A. L.
PY - 1996/8
Y1 - 1996/8
N2 - The aim of this study was to investigate the morphology of the corpus callosum (CC) in Tourette syndrome (TS) and attention deficit hyperactivity disorder (ADHD) to determine whether these conditions affect distinct regional differences. Seventy-seven children and adolescents, aged 6 to 16 years, comprised the four research groups-16 patients with TS, 21 patients with TS plus ADHD, 13 patients with ADHD, and 27 unaffected control subjects. A semiautomated, computer-assisted procedure was used to measure the total area, five subregions, centerline length, perimeter, and bending angle of the CC. MRI data were analyzed using several statistical methods, primarily two- tailed analysis of variance to test the effects of TS and ADHD status, while controlling for the influence of age, gender, and total intracranial area (an estimate of brain size). TS was associated with significant increases in the area of four of five subdivisions, the total area, and the perimeter of the CC. ADHD was associated with a significant decrease in the area of the restral body. There were no interactions between TS and ADHD factors. These findings suggest that the area of the CC is larger in children with TS, and that this difference is independent of age, handedness, intracranial area, and the diagnosis of ADHD. Our findings support hypotheses that the neurobiologic mechanisms in TS and ADHD involve-frontal/subcortical circuits.
AB - The aim of this study was to investigate the morphology of the corpus callosum (CC) in Tourette syndrome (TS) and attention deficit hyperactivity disorder (ADHD) to determine whether these conditions affect distinct regional differences. Seventy-seven children and adolescents, aged 6 to 16 years, comprised the four research groups-16 patients with TS, 21 patients with TS plus ADHD, 13 patients with ADHD, and 27 unaffected control subjects. A semiautomated, computer-assisted procedure was used to measure the total area, five subregions, centerline length, perimeter, and bending angle of the CC. MRI data were analyzed using several statistical methods, primarily two- tailed analysis of variance to test the effects of TS and ADHD status, while controlling for the influence of age, gender, and total intracranial area (an estimate of brain size). TS was associated with significant increases in the area of four of five subdivisions, the total area, and the perimeter of the CC. ADHD was associated with a significant decrease in the area of the restral body. There were no interactions between TS and ADHD factors. These findings suggest that the area of the CC is larger in children with TS, and that this difference is independent of age, handedness, intracranial area, and the diagnosis of ADHD. Our findings support hypotheses that the neurobiologic mechanisms in TS and ADHD involve-frontal/subcortical circuits.
UR - http://www.scopus.com/inward/record.url?scp=0029810019&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029810019&partnerID=8YFLogxK
M3 - Article
C2 - 8757024
AN - SCOPUS:0029810019
VL - 47
SP - 477
EP - 482
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 2
ER -