TY - JOUR
T1 - Corpora amylacea in prostatectomy tissue and associations with molecular, histological, and lifestyle factors
AU - Transdisciplinary Prostate Cancer Partnership(ToPCaP)
AU - DuPre, Natalie C.
AU - Flavin, Richard
AU - Sfanos, Karen S.
AU - Unger, Robert H.
AU - To, Samantha
AU - Gazeeva, Elizaveta
AU - Fiorentino, Michelangelo
AU - De Marzo, Angelo M.
AU - Rider, Jennifer R.
AU - Mucci, Lorelei A.
N1 - Funding Information:
We are grateful to the participants and staff of the Health Professionals Follow-up Study for their valuable contributions. In addition, we would like to thank the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, WY. The Dana-Farber/Harvard Cancer Center Tissue Microarray Core Facility constructed the tissue microarrays in this project, and we would like to thank Chungdak Li for her expert tissue microarray construction. We would also like to thank Samantha To, Catherine Suppan, Michela Loda, and Elizabeth Nuttall for their data collection skills. This work was supported by National Institute of Health (grant numbers R01CA136578, R01CA141298, UM1 CA167552, P50 CA090381); the Prostate Cancer Foundation Young Investigators Awards to LAM, JRR, and the NCI T32 CA09001 to NCD.
Funding Information:
We are grateful to the participants and staff of the Health Professionals Follow-up Study for their valuable contributions. In addition, we would like to thank the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, WY. The Dana-Farber/Harvard Cancer Center Tissue Microarray Core Facility constructed the tissue microarrays in this project, and we would like to thank Chungdak Li for her expert tissue microarray construction. We would also like to thank Samantha To, Catherine Suppan, Michela Loda, and Elizabeth Nuttall for their data collection skills. This work was supported by National Institute of Health (grant numbers R01CA136578, R01CA141298, UM1 CA167552, P50 CA090381); the Prostate Cancer Foundation Young Investigators Awards to LAM, JRR, and the NCI T32 CA09001 to NCD. ND, ST, RU carried out literature searches and drafted the manuscript. ND and ST led the data collection of corpora amylacea after being trained by RF. MF led the histological standardization of the slides. LM and JR developed the study design. ND led the analytical design. ND and EG led the data analyses. All authors were involved in interpreting the data, writing the paper, and had final approval of the submitted manuscript.
Publisher Copyright:
© 2018 Wiley Periodicals, Inc.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Background: Corpora amylacea are amyloid bodies commonly found adjacent to damaged prostate epithelium. Little is known about their formation or function. The current study sought to characterize corpora amylacea in prostate tissue and to describe their relationship with clinical, histological, molecular, and lifestyle factors, especially with chronic inflammation which is associated with aggressive disease. Methods: We studied a cohort of 355 men with prostate cancer and tissue specimens from the Health Professionals Follow-Up Study. Pathologists examined H&E slides and undertook a standardized review for histologic data and inflammation. Trained observers counted corpora amylacea within the benign and predominately tumor areas. Immunohistochemistry biomarkers were available from tissue microarrays. We used multivariable logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) to assess associations of chronic inflammation, clinical, histological, molecular, and lifestyle factors with the presence of corpora amylacea. Results: Corpora amylacea were present in benign tissue area for 298 men (84%). Specimens with moderate-to-severe chronic inflammation were more likely to have corpora amylacea in benign regions (OR = 5.4 95%CI 1.9, 15.6). Moreover, corpora amylacea were more common in men with higher body mass index (OR = 1.13 95%CI 1.01, 1.26). In contrast, Gleason grade (OR = 0.4 95%CI 0.2, 0.8), proliferation index (OR = 0.6 95%CI 0.3, 1.2) and the presence of the TMPRSS2:ERG fusion (OR = 0.4 95%CI 0.2, 0.8) were inversely associated with corpora amylacea presence. TURP specimens were less likely to have corpora amylacea than prostatectomy specimens (OR = 0.12 95%CI 0.03, 0.47). Age, PSA, stage, biomarkers of angiogenesis and PTEN, and vasectomy were not significantly associated with corpora amylacea. Conclusion: Corpora amylacea were common among men with prostate cancer and were associated with pro-inflammatory factors, some markers of less aggressive disease, and lack of the TMPRSS2:ERG fusion.
AB - Background: Corpora amylacea are amyloid bodies commonly found adjacent to damaged prostate epithelium. Little is known about their formation or function. The current study sought to characterize corpora amylacea in prostate tissue and to describe their relationship with clinical, histological, molecular, and lifestyle factors, especially with chronic inflammation which is associated with aggressive disease. Methods: We studied a cohort of 355 men with prostate cancer and tissue specimens from the Health Professionals Follow-Up Study. Pathologists examined H&E slides and undertook a standardized review for histologic data and inflammation. Trained observers counted corpora amylacea within the benign and predominately tumor areas. Immunohistochemistry biomarkers were available from tissue microarrays. We used multivariable logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) to assess associations of chronic inflammation, clinical, histological, molecular, and lifestyle factors with the presence of corpora amylacea. Results: Corpora amylacea were present in benign tissue area for 298 men (84%). Specimens with moderate-to-severe chronic inflammation were more likely to have corpora amylacea in benign regions (OR = 5.4 95%CI 1.9, 15.6). Moreover, corpora amylacea were more common in men with higher body mass index (OR = 1.13 95%CI 1.01, 1.26). In contrast, Gleason grade (OR = 0.4 95%CI 0.2, 0.8), proliferation index (OR = 0.6 95%CI 0.3, 1.2) and the presence of the TMPRSS2:ERG fusion (OR = 0.4 95%CI 0.2, 0.8) were inversely associated with corpora amylacea presence. TURP specimens were less likely to have corpora amylacea than prostatectomy specimens (OR = 0.12 95%CI 0.03, 0.47). Age, PSA, stage, biomarkers of angiogenesis and PTEN, and vasectomy were not significantly associated with corpora amylacea. Conclusion: Corpora amylacea were common among men with prostate cancer and were associated with pro-inflammatory factors, some markers of less aggressive disease, and lack of the TMPRSS2:ERG fusion.
KW - TMPRSS2:ERG
KW - corpora amylacea
KW - epidemiology
KW - inflammation
KW - prostate
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U2 - 10.1002/pros.23692
DO - 10.1002/pros.23692
M3 - Article
C2 - 30009541
AN - SCOPUS:85050933169
SN - 0270-4137
VL - 78
SP - 1172
EP - 1180
JO - Prostate
JF - Prostate
IS - 15
ER -