Coronavirus vaccine development: from SARS and MERS to COVID-19

Yen Der Li, Wei Yu Chi, Jun Han Su, Louise Ferrall, Chien Fu Hung, T. C. Wu

Research output: Contribution to journalReview articlepeer-review

Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a new type of coronavirus that causes the Coronavirus Disease 2019 (COVID-19), which has been the most challenging pandemic in this century. Considering its high mortality and rapid spread, an effective vaccine is urgently needed to control this pandemic. As a result, the academia, industry, and government sectors are working tightly together to develop and test a variety of vaccines at an unprecedented pace. In this review, we outline the essential coronavirus biological characteristics that are important for vaccine design. In addition, we summarize key takeaways from previous vaccination studies of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV), highlighting the pros and cons of each immunization strategy. Finally, based on these prior vaccination experiences, we discuss recent progress and potential challenges of COVID-19 vaccine development.

Original languageEnglish (US)
Article number104
JournalJournal of biomedical science
Volume27
Issue number1
DOIs
StatePublished - Dec 2020

Keywords

  • Coronaviruses
  • SARS-CoV-2
  • Vaccine
  • Vaccine development

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)

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