Coronary vessel wall evaluation by magnetic resonance imaging in the multi-ethnic study of atherosclerosis

Determinants of image quality

Ashkan A. Malayeri, Robson MacEdo, Debiao Li, Shaoguang Chen, Hossein Bahrami, Shenghan Lai, Joao Lima, David A. Bluemke

Research output: Contribution to journalArticle

Abstract

Coronary artery wall magnetic resonance imaging (MRI) has been developed to assess coronary lumen diameter and wall thickness. The purpose of this study was to evaluate the physiological parameters that affect the measures of coronary wall thickness using black-blood MRI pulse sequences. METHODS: Eighty-seven participants (38 men and 49 women) of the Multi-Ethnic Study of Atherosclerosis were enrolled in the coronary artery wall MRI study. Cine 4-chamber imaging was used to determine the coronary artery rest period. Free-breathing whole-heart magnetic resonance angiography with motion adaptor navigator was performed to localize the coronary arteries in 64 participants. Cross-sectional free-breathing black-blood images were acquired using electrocardiogram-gated, turbo spin echo sequence. Imaging parameters were as follows: repetition time = 2 R-R intervals, time to echo = 33 milliseconds, echo train length = 13, bandwidth = 305 Hz/pixel, matrix = 416 × 416, field of view = 420 × 420 mm, and slice thickness = 4 to 5 mm. RESULTS: Imaging was completed in 215 (92%) of 234 coronary segments; 9 participants had incomplete scans. Mean age was 62.6 ± 8.4 years (range, 45-81 years). Mean body mass index was 29.2 ± 5.9 kg/m. A higher proportion of images with quality of "good" was seen in the right coronary artery (40.5%) compared to the left main and left anterior descending coronary arteries (31.9% and 26.4%, respectively). There was a very good agreement between observers in the image quality scores (κ = 0.79, P <0.001). Lower heart rate, male sex, and longer coronary rest period were associated with higher image quality score (P <0.05). Signal-to-noise ratio was higher in participants with Agatston calcium score of more than 10 in the right coronary and left main arteries (48.5 vs 69.7, P = 0.001; and 53.4 vs 61.6, P = 0.032, respectively). CONCLUSION: Improved depiction of the coronary artery wall with MRI is related to coronary rest period and atherosclerotic plaque burden as measured by calcium score and inversely related to heart rate. Because longer coronary artery rest periods are associated with improved image quality both for angiography with MRI and coronary artery wall imaging, heart rate-lowering methods in association with these techniques appear to be a logical application.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalJournal of Computer Assisted Tomography
Volume33
Issue number1
DOIs
StatePublished - Jan 2009

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Atherosclerosis
Coronary Vessels
Magnetic Resonance Imaging
Heart Rate
Respiration
Calcium
Magnetic Resonance Angiography
Signal-To-Noise Ratio
Atherosclerotic Plaques
Angiography
Electrocardiography
Body Mass Index
Arteries

Keywords

  • Cardiac
  • Coronary
  • Image quality
  • Magnetic resonance imaging
  • MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Coronary vessel wall evaluation by magnetic resonance imaging in the multi-ethnic study of atherosclerosis : Determinants of image quality. / Malayeri, Ashkan A.; MacEdo, Robson; Li, Debiao; Chen, Shaoguang; Bahrami, Hossein; Lai, Shenghan; Lima, Joao; Bluemke, David A.

In: Journal of Computer Assisted Tomography, Vol. 33, No. 1, 01.2009, p. 1-7.

Research output: Contribution to journalArticle

Malayeri, Ashkan A. ; MacEdo, Robson ; Li, Debiao ; Chen, Shaoguang ; Bahrami, Hossein ; Lai, Shenghan ; Lima, Joao ; Bluemke, David A. / Coronary vessel wall evaluation by magnetic resonance imaging in the multi-ethnic study of atherosclerosis : Determinants of image quality. In: Journal of Computer Assisted Tomography. 2009 ; Vol. 33, No. 1. pp. 1-7.
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AU - Chen, Shaoguang

AU - Bahrami, Hossein

AU - Lai, Shenghan

AU - Lima, Joao

AU - Bluemke, David A.

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N2 - Coronary artery wall magnetic resonance imaging (MRI) has been developed to assess coronary lumen diameter and wall thickness. The purpose of this study was to evaluate the physiological parameters that affect the measures of coronary wall thickness using black-blood MRI pulse sequences. METHODS: Eighty-seven participants (38 men and 49 women) of the Multi-Ethnic Study of Atherosclerosis were enrolled in the coronary artery wall MRI study. Cine 4-chamber imaging was used to determine the coronary artery rest period. Free-breathing whole-heart magnetic resonance angiography with motion adaptor navigator was performed to localize the coronary arteries in 64 participants. Cross-sectional free-breathing black-blood images were acquired using electrocardiogram-gated, turbo spin echo sequence. Imaging parameters were as follows: repetition time = 2 R-R intervals, time to echo = 33 milliseconds, echo train length = 13, bandwidth = 305 Hz/pixel, matrix = 416 × 416, field of view = 420 × 420 mm, and slice thickness = 4 to 5 mm. RESULTS: Imaging was completed in 215 (92%) of 234 coronary segments; 9 participants had incomplete scans. Mean age was 62.6 ± 8.4 years (range, 45-81 years). Mean body mass index was 29.2 ± 5.9 kg/m. A higher proportion of images with quality of "good" was seen in the right coronary artery (40.5%) compared to the left main and left anterior descending coronary arteries (31.9% and 26.4%, respectively). There was a very good agreement between observers in the image quality scores (κ = 0.79, P <0.001). Lower heart rate, male sex, and longer coronary rest period were associated with higher image quality score (P <0.05). Signal-to-noise ratio was higher in participants with Agatston calcium score of more than 10 in the right coronary and left main arteries (48.5 vs 69.7, P = 0.001; and 53.4 vs 61.6, P = 0.032, respectively). CONCLUSION: Improved depiction of the coronary artery wall with MRI is related to coronary rest period and atherosclerotic plaque burden as measured by calcium score and inversely related to heart rate. Because longer coronary artery rest periods are associated with improved image quality both for angiography with MRI and coronary artery wall imaging, heart rate-lowering methods in association with these techniques appear to be a logical application.

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