Coronary vasomotor control in obesity and morbid obesity: Contrasting flow responses with endocannabinoids, leptin, and inflammation

Alessandra Quercioli, Zoltan Pataky, Fabrizio Montecucco, Sebastian Carballo, Aurlien Thomas, Christian Staub, Vincenzo Di Marzo, Gabriella Vincenti, Giuseppe Ambrosio, Osman Ratib, Alain Golay, Franois MacH, Elisabetta Harsch, Thomas H. Schindler

Research output: Contribution to journalArticle

Abstract

This study sought to investigate abnormalities in coronary circulatory function in 2 different disease entities of obese (OB) and morbidly obese (MOB) individuals and to evaluate whether these would differ in severity with different profiles of endocannabinoids, leptin, and C-reactive protein (CRP) plasma levels. There is increasing evidence that altered plasma levels of endocannabinoids, leptin, and CRP may affect coronary circulatory function in OB and MOB. Myocardial blood flow (MBF) responses to cold pressor test from rest and during pharmacologically induced hyperemia were measured with N-13 ammonia positron emission tomography/computed tomography. Study participants (n = 111) were divided into 4 groups based on their body mass index (BMI) (kg/m 2): 1) control group (BMI: 20 to 24.9, n = 30); 2) overweight group (BMI: 25 to 29.9, n = 31), 3) OB group (BMI: 30 to 39.9, n = 25); and 4) MOB group (BMI

Original languageEnglish (US)
Pages (from-to)805-815
Number of pages11
JournalJACC: Cardiovascular Imaging
Volume5
Issue number8
DOIs
StatePublished - Aug 2012
Externally publishedYes

Fingerprint

Endocannabinoids
Morbid Obesity
Leptin
Body Mass Index
Obesity
Inflammation
C-Reactive Protein
Hyperemia
Ammonia
Control Groups

Keywords

  • 2-AG
  • 2-arachidonoylglycerol
  • AEA
  • analysis of variance
  • anandamide
  • ANOVA
  • BMI
  • body mass index
  • CAC
  • CAD
  • CI
  • cold pressor test
  • computed tomography
  • CON
  • confidence interval
  • control subject(s)
  • coronary artery calcification
  • coronary artery disease
  • coronary vascular resistance
  • CPT
  • CT
  • CVR
  • EC
  • endocannabinoid(s)
  • HDL
  • high-density lipoprotein
  • high-sensitivity C-reactive protein
  • hsCRP
  • MBF
  • MFR
  • MOB
  • morbid obesity
  • myocardial blood flow
  • myocardial flow reserve
  • OB
  • obesity
  • overweight
  • OW
  • PET
  • positron emission tomography
  • rate-pressure product
  • RPP
  • SBP
  • systolic blood pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Coronary vasomotor control in obesity and morbid obesity : Contrasting flow responses with endocannabinoids, leptin, and inflammation. / Quercioli, Alessandra; Pataky, Zoltan; Montecucco, Fabrizio; Carballo, Sebastian; Thomas, Aurlien; Staub, Christian; Di Marzo, Vincenzo; Vincenti, Gabriella; Ambrosio, Giuseppe; Ratib, Osman; Golay, Alain; MacH, Franois; Harsch, Elisabetta; Schindler, Thomas H.

In: JACC: Cardiovascular Imaging, Vol. 5, No. 8, 08.2012, p. 805-815.

Research output: Contribution to journalArticle

Quercioli, A, Pataky, Z, Montecucco, F, Carballo, S, Thomas, A, Staub, C, Di Marzo, V, Vincenti, G, Ambrosio, G, Ratib, O, Golay, A, MacH, F, Harsch, E & Schindler, TH 2012, 'Coronary vasomotor control in obesity and morbid obesity: Contrasting flow responses with endocannabinoids, leptin, and inflammation', JACC: Cardiovascular Imaging, vol. 5, no. 8, pp. 805-815. https://doi.org/10.1016/j.jcmg.2012.01.020
Quercioli, Alessandra ; Pataky, Zoltan ; Montecucco, Fabrizio ; Carballo, Sebastian ; Thomas, Aurlien ; Staub, Christian ; Di Marzo, Vincenzo ; Vincenti, Gabriella ; Ambrosio, Giuseppe ; Ratib, Osman ; Golay, Alain ; MacH, Franois ; Harsch, Elisabetta ; Schindler, Thomas H. / Coronary vasomotor control in obesity and morbid obesity : Contrasting flow responses with endocannabinoids, leptin, and inflammation. In: JACC: Cardiovascular Imaging. 2012 ; Vol. 5, No. 8. pp. 805-815.
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AU - Carballo, Sebastian

AU - Thomas, Aurlien

AU - Staub, Christian

AU - Di Marzo, Vincenzo

AU - Vincenti, Gabriella

AU - Ambrosio, Giuseppe

AU - Ratib, Osman

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