Coronary intervention in the diabetic patient: Improved outcome following stent implantation compared with balloon angioplasty

Michael P. Savage, David L. Fischman, Richard A. Schatz, Martin B. Leon, Donald S. Baim, Jeffrey Brinker, John Hirshfeld, Sheldon Goldberg

Research output: Contribution to journalArticlepeer-review


Background: Diabetic patients undergoing coronary interventional procedures are at increased risk of restenosis and adverse clinical events. The relative impact of stents compared with balloon angioplasty on the outcome of percutaneous intervention in diabetics remains controversial. Hypothesis: The goal of this study was to determine whether stent placement was superior to balloon angioplasty in reducing restenosis of diabetic patients undergoing coronary intervention. Methods: The STRESS Trial was a prospective randomized comparison of stent placement and balloon angioplasty in the treatment of new native coronary lesions. Of 594 randomized patients, 92 (16%) were diabetic. In this substudy analysis of the STRESS Trial, the outcomes after stenting and balloon angioplasty in diabetic patients were compared. The primary endpoint was restenosis as determined by angiography at 6 months. Clinical outcomes at I year were assessed. Results: Procedural success was achieved in 82% of diabetic patients assigned to angioplasty and in 100% assigned to stenting (p<0.01). Compared with angioplasty, stenting resulted in a larger postprocedural lumen diameter (2.34 ± 0.44 vs. 1.87 ± 0.52 mm, p<0.001) and greater acute luminal gain (1.61 ± 0.47 vs. 1.06 ± 0.46 mm, p<0.001). At 6 months, stenting conferred a larger lumen (1.69 ± 0.57 vs. 1.38 ± 0.60 mm, p = 0.03) and greater net luminal gain (0.97 ± 0.55 vs. 0.52 ± 0.52 mm, p<0.001). Restenosis occurred in 60% of the angioplasty group and in 24% of the stent group (p<0.01). This was accompanied by a lower need for repeat target vessel revascu- larization after stenting (31 vs. 13%, p<0.03). Conclusions: Compared with balloon angioplasty, stent placement in diabetic patients with focal de novo lesions resulted in superior procedural results, reduced restenosis, and improved clinical outcome with fewer repeat revascularization procedures.

Original languageEnglish (US)
Pages (from-to)213-217
Number of pages5
JournalClinical Cardiology
Issue number5
StatePublished - Jan 1 2002


  • Coronary angioplasty
  • Diabetes
  • Restenosis
  • Stent

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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