Coronary CT angiography: Variability of CT scanners and readers in measurement of plaque volume

Rolf Symons, Justin Z. Morris, Colin O. Wu, Amir Pourmorteza, Mark A. Ahlman, João A.C. Lima, Marcus Y. Chen, Marissa Mallek, Veit Sandfort, David A. Bluemke

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Purpose: To determine reader and computed tomography (CT) scan variability for measurement of coronary plaque volume. Materials and Methods: This HIPAA-compliant study followed Standards for Reporting of Diagnostic Accuracy guidelines. Baseline coronary CT angiography was performed in 40 prospectively enrolled subjects (mean age, 67 years 6 6 [standard deviation]) with asymptomatic hyperlipidemia by using a 320-detector row scanner (Aquilion One Vision; Toshiba, Otawara, Japan). Twenty of these subjects underwent coronary CT angiography repeated on a separate day with the same CT scanner (Toshiba, group 1); 20 subjects underwent repeat CT performed with a different CT scanner (Somatom Force; Siemens, Forchheim, Germany [group 2]). Intraclass correlation coefficients (ICCs) and Bland- Altman analysis were used to assess interreader, intrareader, and interstudy reproducibility. Results: Baseline and repeat coronary CT angiography scans were acquired within 19 days 6 6. Interreader and intrareader agreement rates were high for total, calcified, and noncalcified plaques for both CT scanners (all ICCs 0.96) without bias. Scanner variability was 618.4% (coefficient of variation) with same-vendor follow-up. However, scanner variability increased to 629.9% with different-vendor follow-up. The sample size to detect a 5% change in noncalcified plaque volume with 90% power and an a error of .05 was 286 subjects for same-CT scanner follow-up and 753 subjects with different-vendor follow-up. Conclusion: State-of-the-art coronary CT angiography with same-vendor follow-up has good scan-rescan reproducibility, suggesting a role of coronary CT angiography in monitoring coronary artery plaque response to therapy. Differences between coronary CT angiography vendors resulted in lower scanrescan reproducibility.

Original languageEnglish (US)
Pages (from-to)737-748
Number of pages12
Issue number3
StatePublished - Dec 2016

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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