Coronary calcium as a predictor of coronary events in four racial or ethnic groups

Robert Detrano, Alan D. Guerci, J. Jeffrey Carr, Diane E. Bild, Gregory Burke, Aaron R. Folsom, Kiang Liu, Steven Shea, Moyses Szklo, David A. Bluemke, Daniel H. O'Leary, Russell Tracy, Karol Watson, Nathan D. Wong, Richard A. Kronmal

Research output: Contribution to journalArticle

Abstract

BACKGROUND: In white populations, computed tomographic measurements of coronary-artery calcium predict coronary heart disease independently of traditional coronary risk factors. However, it is not known whether coronary-artery calcium predicts coronary heart disease in other racial or ethnic groups. METHODS: We collected data on risk factors and performed scanning for coronary calcium in a population-based sample of 6722 men and women, of whom 38.6% were white, 27.6% were black, 21.9% were Hispanic, and 11.9% were Chinese. The study subjects had no clinical cardiovascular disease at entry and were followed for a median of 3.8 years. RESULTS: There were 162 coronary events, of which 89 were major events (myocardial infarction or death from coronary heart disease). In comparison with participants with no coronary calcium, the adjusted risk of a coronary event was increased by a factor of 7.73 among participants with coronary calcium scores between 101 and 300 and by a factor of 9.67 among participants with scores above 300 (P

Original languageEnglish (US)
Pages (from-to)1336-1345
Number of pages10
JournalNew England Journal of Medicine
Volume358
Issue number13
DOIs
StatePublished - Mar 27 2008

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Ethnic Groups
Calcium
Coronary Disease
Coronary Vessels
Hispanic Americans
Population
Cardiovascular Diseases
Myocardial Infarction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Detrano, R., Guerci, A. D., Carr, J. J., Bild, D. E., Burke, G., Folsom, A. R., ... Kronmal, R. A. (2008). Coronary calcium as a predictor of coronary events in four racial or ethnic groups. New England Journal of Medicine, 358(13), 1336-1345. https://doi.org/10.1056/NEJMoa072100

Coronary calcium as a predictor of coronary events in four racial or ethnic groups. / Detrano, Robert; Guerci, Alan D.; Carr, J. Jeffrey; Bild, Diane E.; Burke, Gregory; Folsom, Aaron R.; Liu, Kiang; Shea, Steven; Szklo, Moyses; Bluemke, David A.; O'Leary, Daniel H.; Tracy, Russell; Watson, Karol; Wong, Nathan D.; Kronmal, Richard A.

In: New England Journal of Medicine, Vol. 358, No. 13, 27.03.2008, p. 1336-1345.

Research output: Contribution to journalArticle

Detrano, R, Guerci, AD, Carr, JJ, Bild, DE, Burke, G, Folsom, AR, Liu, K, Shea, S, Szklo, M, Bluemke, DA, O'Leary, DH, Tracy, R, Watson, K, Wong, ND & Kronmal, RA 2008, 'Coronary calcium as a predictor of coronary events in four racial or ethnic groups', New England Journal of Medicine, vol. 358, no. 13, pp. 1336-1345. https://doi.org/10.1056/NEJMoa072100
Detrano R, Guerci AD, Carr JJ, Bild DE, Burke G, Folsom AR et al. Coronary calcium as a predictor of coronary events in four racial or ethnic groups. New England Journal of Medicine. 2008 Mar 27;358(13):1336-1345. https://doi.org/10.1056/NEJMoa072100
Detrano, Robert ; Guerci, Alan D. ; Carr, J. Jeffrey ; Bild, Diane E. ; Burke, Gregory ; Folsom, Aaron R. ; Liu, Kiang ; Shea, Steven ; Szklo, Moyses ; Bluemke, David A. ; O'Leary, Daniel H. ; Tracy, Russell ; Watson, Karol ; Wong, Nathan D. ; Kronmal, Richard A. / Coronary calcium as a predictor of coronary events in four racial or ethnic groups. In: New England Journal of Medicine. 2008 ; Vol. 358, No. 13. pp. 1336-1345.
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AU - Guerci, Alan D.

AU - Carr, J. Jeffrey

AU - Bild, Diane E.

AU - Burke, Gregory

AU - Folsom, Aaron R.

AU - Liu, Kiang

AU - Shea, Steven

AU - Szklo, Moyses

AU - Bluemke, David A.

AU - O'Leary, Daniel H.

AU - Tracy, Russell

AU - Watson, Karol

AU - Wong, Nathan D.

AU - Kronmal, Richard A.

PY - 2008/3/27

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N2 - BACKGROUND: In white populations, computed tomographic measurements of coronary-artery calcium predict coronary heart disease independently of traditional coronary risk factors. However, it is not known whether coronary-artery calcium predicts coronary heart disease in other racial or ethnic groups. METHODS: We collected data on risk factors and performed scanning for coronary calcium in a population-based sample of 6722 men and women, of whom 38.6% were white, 27.6% were black, 21.9% were Hispanic, and 11.9% were Chinese. The study subjects had no clinical cardiovascular disease at entry and were followed for a median of 3.8 years. RESULTS: There were 162 coronary events, of which 89 were major events (myocardial infarction or death from coronary heart disease). In comparison with participants with no coronary calcium, the adjusted risk of a coronary event was increased by a factor of 7.73 among participants with coronary calcium scores between 101 and 300 and by a factor of 9.67 among participants with scores above 300 (P

AB - BACKGROUND: In white populations, computed tomographic measurements of coronary-artery calcium predict coronary heart disease independently of traditional coronary risk factors. However, it is not known whether coronary-artery calcium predicts coronary heart disease in other racial or ethnic groups. METHODS: We collected data on risk factors and performed scanning for coronary calcium in a population-based sample of 6722 men and women, of whom 38.6% were white, 27.6% were black, 21.9% were Hispanic, and 11.9% were Chinese. The study subjects had no clinical cardiovascular disease at entry and were followed for a median of 3.8 years. RESULTS: There were 162 coronary events, of which 89 were major events (myocardial infarction or death from coronary heart disease). In comparison with participants with no coronary calcium, the adjusted risk of a coronary event was increased by a factor of 7.73 among participants with coronary calcium scores between 101 and 300 and by a factor of 9.67 among participants with scores above 300 (P

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