Coronary Artery Calcium Score and Association with Recurrent Nephrolithiasis: The Multi-Ethnic Study of Atherosclerosis

Ryan S. Hsi, Andrew J. Spieker, Marshall L. Stoller, David R. Jacobs, Alex P. Reiner, Robyn L. McClelland, Arnold J. Kahn, Thomas Chi, Moyses Szklo, Mathew D. Sorensen

Research output: Contribution to journalArticle

Abstract

PURPOSE: Subclinical coronary artery calcification is an established predictor of cardiovascular events. While a history of kidney stones has been linked to subclinical carotid atherosclerosis, to our knowledge no study has examined its relationship with coronary artery calcification. We studied the association between kidney stone history and prevalent coronary artery calcification in MESA (Multi-Ethnic Study of Atherosclerosis).

MATERIALS AND METHODS: MESA is a multisite cohort study of participants 45 to 84 years old without known cardiovascular disease at baseline from 2000 to 2002. Computerized tomography was done in 3,282 participants at followup in 2010 to 2012 to determine coronary artery calcification and kidney stone history was assessed by self-report. Coronary artery calcification scores were categorized as none-0, mild-1 to 99, moderate-100 to 399 or severe-400 or greater. Cross-sectional analysis was performed adjusting for demographic and dietary factors related to kidney stones.

RESULTS: The prevalence of kidney stone disease history was approximately 9%, mean ± SD participant age was 69.5 ± 9.3 years, 39% of participants were Caucasian, 47% were men and 69% had detectable coronary artery calcification (score greater than 0). No difference in the score was seen between single stone formers and nonstone formers. Recurrent kidney stone formation was associated with moderate or severe calcification on multivariable logistic regression vs none or mild calcification (OR 1.80, 95% CI 1.22-2.67). When coronary artery calcification scores were separated into none, mild, moderate and severe calcification, recurrent stone formation was associated with a higher score category on multivariable ordinal logistic regression (OR 1.44 per category, 95% CI 1.04-2.01).

CONCLUSIONS: Recurrent kidney stone formation is associated with subclinical coronary atherosclerosis. This association appeared stronger with coronary artery calcification severity than with coronary artery calcification presence.

Original languageEnglish (US)
Pages (from-to)971-976
Number of pages6
JournalThe Journal of Urology
Volume195
Issue number4
DOIs
StatePublished - Apr 1 2016

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Nephrolithiasis
Kidney Calculi
Atherosclerosis
Coronary Vessels
Calcium
Logistic Models
Carotid Artery Diseases
Kidney Diseases
Self Report
Coronary Artery Disease
Cohort Studies
Cardiovascular Diseases
Cross-Sectional Studies
Tomography
Demography

Keywords

  • arteriosclerosis
  • coronary artery disease
  • kidney
  • recurrence
  • urolithiasis

ASJC Scopus subject areas

  • Urology

Cite this

Hsi, R. S., Spieker, A. J., Stoller, M. L., Jacobs, D. R., Reiner, A. P., McClelland, R. L., ... Sorensen, M. D. (2016). Coronary Artery Calcium Score and Association with Recurrent Nephrolithiasis: The Multi-Ethnic Study of Atherosclerosis. The Journal of Urology, 195(4), 971-976. https://doi.org/10.1016/j.juro.2015.10.001

Coronary Artery Calcium Score and Association with Recurrent Nephrolithiasis : The Multi-Ethnic Study of Atherosclerosis. / Hsi, Ryan S.; Spieker, Andrew J.; Stoller, Marshall L.; Jacobs, David R.; Reiner, Alex P.; McClelland, Robyn L.; Kahn, Arnold J.; Chi, Thomas; Szklo, Moyses; Sorensen, Mathew D.

In: The Journal of Urology, Vol. 195, No. 4, 01.04.2016, p. 971-976.

Research output: Contribution to journalArticle

Hsi, RS, Spieker, AJ, Stoller, ML, Jacobs, DR, Reiner, AP, McClelland, RL, Kahn, AJ, Chi, T, Szklo, M & Sorensen, MD 2016, 'Coronary Artery Calcium Score and Association with Recurrent Nephrolithiasis: The Multi-Ethnic Study of Atherosclerosis', The Journal of Urology, vol. 195, no. 4, pp. 971-976. https://doi.org/10.1016/j.juro.2015.10.001
Hsi, Ryan S. ; Spieker, Andrew J. ; Stoller, Marshall L. ; Jacobs, David R. ; Reiner, Alex P. ; McClelland, Robyn L. ; Kahn, Arnold J. ; Chi, Thomas ; Szklo, Moyses ; Sorensen, Mathew D. / Coronary Artery Calcium Score and Association with Recurrent Nephrolithiasis : The Multi-Ethnic Study of Atherosclerosis. In: The Journal of Urology. 2016 ; Vol. 195, No. 4. pp. 971-976.
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abstract = "PURPOSE: Subclinical coronary artery calcification is an established predictor of cardiovascular events. While a history of kidney stones has been linked to subclinical carotid atherosclerosis, to our knowledge no study has examined its relationship with coronary artery calcification. We studied the association between kidney stone history and prevalent coronary artery calcification in MESA (Multi-Ethnic Study of Atherosclerosis).MATERIALS AND METHODS: MESA is a multisite cohort study of participants 45 to 84 years old without known cardiovascular disease at baseline from 2000 to 2002. Computerized tomography was done in 3,282 participants at followup in 2010 to 2012 to determine coronary artery calcification and kidney stone history was assessed by self-report. Coronary artery calcification scores were categorized as none-0, mild-1 to 99, moderate-100 to 399 or severe-400 or greater. Cross-sectional analysis was performed adjusting for demographic and dietary factors related to kidney stones.RESULTS: The prevalence of kidney stone disease history was approximately 9{\%}, mean ± SD participant age was 69.5 ± 9.3 years, 39{\%} of participants were Caucasian, 47{\%} were men and 69{\%} had detectable coronary artery calcification (score greater than 0). No difference in the score was seen between single stone formers and nonstone formers. Recurrent kidney stone formation was associated with moderate or severe calcification on multivariable logistic regression vs none or mild calcification (OR 1.80, 95{\%} CI 1.22-2.67). When coronary artery calcification scores were separated into none, mild, moderate and severe calcification, recurrent stone formation was associated with a higher score category on multivariable ordinal logistic regression (OR 1.44 per category, 95{\%} CI 1.04-2.01).CONCLUSIONS: Recurrent kidney stone formation is associated with subclinical coronary atherosclerosis. This association appeared stronger with coronary artery calcification severity than with coronary artery calcification presence.",
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AU - Spieker, Andrew J.

AU - Stoller, Marshall L.

AU - Jacobs, David R.

AU - Reiner, Alex P.

AU - McClelland, Robyn L.

AU - Kahn, Arnold J.

AU - Chi, Thomas

AU - Szklo, Moyses

AU - Sorensen, Mathew D.

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N2 - PURPOSE: Subclinical coronary artery calcification is an established predictor of cardiovascular events. While a history of kidney stones has been linked to subclinical carotid atherosclerosis, to our knowledge no study has examined its relationship with coronary artery calcification. We studied the association between kidney stone history and prevalent coronary artery calcification in MESA (Multi-Ethnic Study of Atherosclerosis).MATERIALS AND METHODS: MESA is a multisite cohort study of participants 45 to 84 years old without known cardiovascular disease at baseline from 2000 to 2002. Computerized tomography was done in 3,282 participants at followup in 2010 to 2012 to determine coronary artery calcification and kidney stone history was assessed by self-report. Coronary artery calcification scores were categorized as none-0, mild-1 to 99, moderate-100 to 399 or severe-400 or greater. Cross-sectional analysis was performed adjusting for demographic and dietary factors related to kidney stones.RESULTS: The prevalence of kidney stone disease history was approximately 9%, mean ± SD participant age was 69.5 ± 9.3 years, 39% of participants were Caucasian, 47% were men and 69% had detectable coronary artery calcification (score greater than 0). No difference in the score was seen between single stone formers and nonstone formers. Recurrent kidney stone formation was associated with moderate or severe calcification on multivariable logistic regression vs none or mild calcification (OR 1.80, 95% CI 1.22-2.67). When coronary artery calcification scores were separated into none, mild, moderate and severe calcification, recurrent stone formation was associated with a higher score category on multivariable ordinal logistic regression (OR 1.44 per category, 95% CI 1.04-2.01).CONCLUSIONS: Recurrent kidney stone formation is associated with subclinical coronary atherosclerosis. This association appeared stronger with coronary artery calcification severity than with coronary artery calcification presence.

AB - PURPOSE: Subclinical coronary artery calcification is an established predictor of cardiovascular events. While a history of kidney stones has been linked to subclinical carotid atherosclerosis, to our knowledge no study has examined its relationship with coronary artery calcification. We studied the association between kidney stone history and prevalent coronary artery calcification in MESA (Multi-Ethnic Study of Atherosclerosis).MATERIALS AND METHODS: MESA is a multisite cohort study of participants 45 to 84 years old without known cardiovascular disease at baseline from 2000 to 2002. Computerized tomography was done in 3,282 participants at followup in 2010 to 2012 to determine coronary artery calcification and kidney stone history was assessed by self-report. Coronary artery calcification scores were categorized as none-0, mild-1 to 99, moderate-100 to 399 or severe-400 or greater. Cross-sectional analysis was performed adjusting for demographic and dietary factors related to kidney stones.RESULTS: The prevalence of kidney stone disease history was approximately 9%, mean ± SD participant age was 69.5 ± 9.3 years, 39% of participants were Caucasian, 47% were men and 69% had detectable coronary artery calcification (score greater than 0). No difference in the score was seen between single stone formers and nonstone formers. Recurrent kidney stone formation was associated with moderate or severe calcification on multivariable logistic regression vs none or mild calcification (OR 1.80, 95% CI 1.22-2.67). When coronary artery calcification scores were separated into none, mild, moderate and severe calcification, recurrent stone formation was associated with a higher score category on multivariable ordinal logistic regression (OR 1.44 per category, 95% CI 1.04-2.01).CONCLUSIONS: Recurrent kidney stone formation is associated with subclinical coronary atherosclerosis. This association appeared stronger with coronary artery calcification severity than with coronary artery calcification presence.

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KW - kidney

KW - recurrence

KW - urolithiasis

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