Coronary artery calcium for the prediction of mortality in young adults 75 years old

Rajesh Tota-Maharaj, Michael Blaha, John W. McEvoy, Roger S Blumenthal, Evan D. Muse, Matthew J. Budoff, Leslee J. Shaw, Daniel S. Berman, Jamal S. Rana, John Rumberger, Tracy Callister, Juan Rivera, Arthur Agatston, Khurram Nasir

Research output: Contribution to journalArticle

Abstract

Aims To determine if coronary artery calcium (CAC) scoring is independently predictive of mortality in young adults and in the elderly population and if a young person with high CAC has a higher mortality risk than an older person with less CAC. Methods and resultsWe studied a cohort of 44 052 asymptomatic patients referred for CAC scans for cardiovascular risk stratification. All-cause mortality rates (MRs) were calculated after stratifying by age groups (400). Multivariable Cox regression models were constructed to assess the independent value of CAC for predicting all-cause mortality in the 400, 34.6 (15.5-77.4); ≥75 age group: CAC = 1-100, 7.0 (2.4-20.8); CAC = 100-400, 9.2 (3.2-26.5); CAC > 400, 16.1 (5.8-45.1)]. Persons 400 had 2-and 10-fold increased MRs, respectively, compared with persons ≥75 with no CAC. Individuals ≥75 years old with CAC = 0 had a 5.6-year survival rate of 98%, similar to those in other age groups with CAC = 0 (5.6-year survival, 99%).ConclusionThe value of CAC for predicting mortality extends to both elderly patients and those

Original languageEnglish (US)
Pages (from-to)2955-2962
Number of pages8
JournalEuropean Heart Journal
Volume33
Issue number23
DOIs
StatePublished - Dec 2012

Fingerprint

Young Adult
Coronary Vessels
Calcium
Mortality
Age Groups
Proportional Hazards Models
Survival Rate
Survival

Keywords

  • Ageing
  • Coronary artery calcium
  • Coronary CT
  • Coronary heart disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Coronary artery calcium for the prediction of mortality in young adults 75 years old. / Tota-Maharaj, Rajesh; Blaha, Michael; McEvoy, John W.; Blumenthal, Roger S; Muse, Evan D.; Budoff, Matthew J.; Shaw, Leslee J.; Berman, Daniel S.; Rana, Jamal S.; Rumberger, John; Callister, Tracy; Rivera, Juan; Agatston, Arthur; Nasir, Khurram.

In: European Heart Journal, Vol. 33, No. 23, 12.2012, p. 2955-2962.

Research output: Contribution to journalArticle

Tota-Maharaj, R, Blaha, M, McEvoy, JW, Blumenthal, RS, Muse, ED, Budoff, MJ, Shaw, LJ, Berman, DS, Rana, JS, Rumberger, J, Callister, T, Rivera, J, Agatston, A & Nasir, K 2012, 'Coronary artery calcium for the prediction of mortality in young adults 75 years old', European Heart Journal, vol. 33, no. 23, pp. 2955-2962. https://doi.org/10.1093/eurheartj/ehs230
Tota-Maharaj, Rajesh ; Blaha, Michael ; McEvoy, John W. ; Blumenthal, Roger S ; Muse, Evan D. ; Budoff, Matthew J. ; Shaw, Leslee J. ; Berman, Daniel S. ; Rana, Jamal S. ; Rumberger, John ; Callister, Tracy ; Rivera, Juan ; Agatston, Arthur ; Nasir, Khurram. / Coronary artery calcium for the prediction of mortality in young adults 75 years old. In: European Heart Journal. 2012 ; Vol. 33, No. 23. pp. 2955-2962.
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